Cariprazine impurity 1
Based on 1 Customer Validation
Cariprazine impurity 1 is a dopamine D2 receptor (D2R) agonist. Cariprazine impurity 1 modulates D2R-mediated Gi/o signaling pathway to inhibit cAMP production, and regulates D2R-mediated β-arrestin2 recruitment pathway.
For research use only. We do not sell to patients.
- CAS No.: 791778-53-5
- Formula: C18H27Cl2N3
- Molecular Weight:356.34
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
All Dopamine Receptor Isoforms
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Biological Activity
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D2 Receptor |
Cariprazine impurity 1 (Compound 11) acts as a balanced partial agonist of human D2R, mediates Gi/o-dependent cAMP inhibition (with an EC50 of 0.7 nM) and β-arrestin2 recruitment (with an EC50 of 2 nM), and exhibits a mild bias toward the Gi/o signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 791778-53-5
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Appearance Solid
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Molecular Weight 356.34
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Formula C18H27Cl2N3
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SMILES
ClC1=C(N2CCN(CC[C@H]3CC[C@H](N)CC3)CC2)C=CC=C1Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)