1637532-83-2
Chemical Structure
PM-81I
- CAS No.: 1637532-83-2
- Formula:C43H58F2N3O10P
- Molecular Weight:845.91
IUPAC Name: ((((4-((E)-4-(((S)-3,3-dimethyl-1-oxo-1-((S)-2-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidin-1-yl)butan-2-yl)amino)-4-oxobut-2-en-2-yl)phenyl)difluoromethyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)
InChIKey: RWUNEWNLTKQICG-KDRQYZKKSA-N
SMILES: O=C(N1CC2=CC=CC=C2CC1)[C@H]3N(CCC3)C([C@H](C(C)(C)C)NC(/C=C(C4=CC=C(C=C4)C(F)(F)P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)\C)=O)=O
Biological Activity: PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1].
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PM-81I | 99.91% | PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer. | ||||||||||||||||||||
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Keywords
