1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. PM-81I

PM-81I 

Cat. No.: HY-148093
Handling Instructions

PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1].

For research use only. We do not sell to patients.

PM-81I Chemical Structure

PM-81I Chemical Structure

CAS No. : 1637532-83-2

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Description

PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1].

IC50 & Target

STAT6[1].

In Vitro

PM-81I (0.05, 0.1, 0.5, 1, 2.5, 5 µM; 2 h) inhibits IL-4 stimulated phosphorylation of STAT6 in Bease-2B immortalized human epithelial airway cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Bease-2B immortalized human epithelial airway cells
Concentration: 0.05, 0.1, 0.5, 1, 2.5, 5 µM
Incubation Time: 2 h
Result: Decreased phosphorylation levels of STAT6 to18%, 13%, 13% when at 1, 2.5 and 5 µM, respectively.
Molecular Weight

845.91

Formula

C43H58F2N3O10P

CAS No.
SMILES

O=C(N1CC2=CC=CC=C2CC1)[[email protected]]3N(CCC3)C([[email protected]](C(C)(C)C)NC(/C=C(C4=CC=C(C=C4)C(F)(F)P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)\C)=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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PM-81I
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