477-73-6
Chemical Structure
Safranin
Synonym(s): Safranine T
- CAS No.: 477-73-6
- Formula:C20H19ClN4
- Molecular Weight:350.85
IUPAC Name: 3,7-diamino-2,8-dimethyl-5-phenylphenazin-5-ium chloride
InChIKey: OARRHUQTFTUEOS-UHFFFAOYSA-N
SMILES: CC1=CC2=NC3=C([N+](C4=CC=CC=C4)=C2C=C1N)C=C(N)C(C)=C3.[Cl-]
Biological Activity: Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. Safranin can readily intercalate into biological macromolecules, including DNA and proteins. Safranin has antibacterial effects against gram-positive bacteria (S. aureus). Safranin can be used as a redox indicator in the determination of metal ion concentration[1][2][3][4].
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Safranin | Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. Safranin can readily intercalate into biological macromolecules, including DNA and proteins. Safranin has antibacterial effects against gram-positive bacteria (S. aureus). Safranin can be used as a redox indicator in the determination of metal ion concentration. | |||||||||||||||||||||
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References
- [1]. Wan H, et al. Structure characterization and optical properties investigation of the four main components of the classical phenazinium dye Safranin O. Analyst. 2019;144(24):7149-7156. [Content Brief]
- [2]. Swain D, et al. Differential staining of the cell cycle of plant cells using safranin and indigo-picrocarmine. Stain Technol. 1990;65(4):197-204. [Content Brief]
- [3]. Krumschnabel G, et al. Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol. 2014;542:163-81. [Content Brief]
- [4]. Al-Khikani F, et al. The Antibacterial Action of Safranin and Gentian Violet. Rambam Maimonides Med J. 2022 Jul 31;13(3):e0018. [Content Brief]
