482-22-4
482-22-4
Chemical Structure
(-)-Cryptopleurine
Synonym(s): (R)-Cryptopleurine; NSC 19912
- CAS No.: 482-22-4
- Formula:C24H27NO3
- Molecular Weight:377.48
IUPAC Name: (R)-2,3,6-trimethoxy-11,12,13,14,14a,15-hexahydro-9H-dibenzo[f,h]pyrido[1,2-b]isoquinoline
InChIKey: RSHYSOGXGSUUIJ-OAHLLOKOSA-N
SMILES: COC1=CC2=C3C=C(C(OC)=CC3=C4C[C@]5(CCCCN5CC4=C2C=C1)[H])OC
Biological Activity: (–)-Cryptopleurine is an alkaloid that has been found in Lauraceae and has diverse biological activities. It inhibits the growth of human A375 melanoma, A431 epidermoid carcinoma, A549 lung, MES-SA uterine sarcoma, and MCF-7 breast cancer cells (IC50=3 nM for all).2 (–)-Cryptopleurine inhibits hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay (IC50=8.7 nM).3 (–)-Cryptopleurine (500 μg/mL) prevents lesion formation in tobacco (N. tabacum) plants infected with tobacco mosaic virus (TMV). It also inhibits protein synthesis by yeast and mammalian ribosomes.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(-)-Cryptopleurine | 98% | (–)-Cryptopleurine is an alkaloid that has been found in Lauraceae and has diverse biological activities. It inhibits the growth of human A375 melanoma, A431 epidermoid carcinoma, A549 lung, MES-SA uterine sarcoma, and MCF-7 breast cancer cells (IC50=3 nM for all).2 (–)-Cryptopleurine inhibits hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay (IC50=8.7 nM).3 (–)-Cryptopleurine (500 μg/mL) prevents lesion formation in tobacco (N. tabacum) plants infected with tobacco mosaic virus (TMV). It also inhibits protein synthesis by yeast and mammalian ribosomes. | ||||||||||||||||||||
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Tylophorine | Tylophorine and its analogs are benzoindole alkaloids, most of which are derived from Garcinia plants. Tylophorine analogs all show potent growth inhibition against human hepatocellular carcinoma HepG2 and human nasopharyngeal carcinoma KB cell lines. Tylophorine analogs can also induce increased albumin expression and inhibit α-fetoprotein expression in HepG2 cells, and have the potential to induce HepG2 cell differentiation. | |||||||||||||||||||||
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(-)-Tylophorine | (-)-Tylophorine ((-)-(R)-Tylophorine) is a potent cytotoxic agent with activity against both drug-sensitive and multidrug-resistant cancer cell lines. (-)-Tylophorine has been explored in biomedical research for its anticancer applications. | |||||||||||||||||||||
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Tylocrebrine | Tylocrebrine is a compound with anticancer activity. Its clinical research was interrupted due to toxicity issues. By making it into targeted nanoparticles, its inhibitory index can be improved, the killing effect on tumor cells can be enhanced and brain penetration can be reduced. | |||||||||||||||||||||
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Tylophorinicine | Tylophorinicine is an anti-leukemic and anti-fungal agent. Tylophorinicine exhibits minimum inhibitory concentrations (MIC) in the range of 2-4 mg/mL for TdnH and 0.6-2.5 mg/mL for TnnH against Candida species. Tylophorinicine is a phenanthroindolizidine alkaloid from tylophora asthamatica and pergulatia pallid. Tylophorinicine inhibits thymidylate synthase by pergularinine. | |||||||||||||||||||||
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NK007 | NK007 is a novel anti-SARS-CoV-2 agent with an EC50 value of 30 nM. | |||||||||||||||||||||
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10S,13aR-Antofine N-oxide | 10S,13aR-Antofine N-oxide is a phenanthroindolizidine N-oxide alkaloid and cytotoxic agent found in Cynanchum vincetoxicum. 10S,13aR-Antofine N-oxide exerts cytotoxic effects in drug-sensitive (KB-3-1, IC50 = 0.11 μM) and multi-drug-resistant (KB-V1, IC50 = 0.16 μM) carcinoma cells. 10S, 13aR-Antofine N-oxide acts as a poor substrate for the P-glycoprotein (P-170) efflux pump. 10S,13aR-Antofine N-oxide can be used for the research of cancers. | |||||||||||||||||||||
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Tylophoridicine F | Tylophoridicine F is a cytotoxic agent. Tylophoridicine F can be isolated from T. atrofolliculata. Tylophoridicine F exhibits more cytotoxic activity on cells compared to Adriamycin (assessed using ileocecal adenocarcinoma cells and keratin-forming tumor cells). | |||||||||||||||||||||
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O-Methyltylophorinidine | O-Methyltylophorinidine is a natural product that can be found in Tylophora ovata. | |||||||||||||||||||||
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7-Demethoxytylophorine N-oxide | 7-Demethoxytylophorine N-oxide is an alkaloid inhibitor of Tobacco Mosaic Virus. 7-Demethoxytylophorine N-oxide can be isolated from the aerial parts of Cynanchum komarovii. 7-Demethoxytylophorine N-oxide is applicable to research related to Tobacco Mosaic Virus infection. | |||||||||||||||||||||
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(-)-Antofine | 99.40% | (-)-Antofine is an alkaloid, a levorotatory Antofine. Antofine is an antifungal compound. | ||||||||||||||||||||
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