552-94-3
Chemical Structure
Salsalate
Synonym(s): Salicylsalicylic acid; Disalicylic acid
- CAS No.: 552-94-3
- Formula:C14H10O5
- Molecular Weight:258.23
IUPAC Name: 2-((2-hydroxybenzoyl)oxy)benzoic acid
InChIKey: WVYADZUPLLSGPU-UHFFFAOYSA-N
SMILES: O=C(OC1=CC=CC=C1C(O)=O)C2=CC=CC=C2O
Biological Activity: Salsalate is a potent antirheumatic drug with oral activity that reduces irritation during gastric absorption and avoids direct inhibition of cyclooxygenase. Salsalate not only has significant anti-inflammatory effects, but also reduces blood sugar levels, improves insulin resistance, and reduces the expression of cytokines. Salsalate can protect mice from metabolic disorders caused by high-fat diet and effectively improve the symptoms of type 2 diabetes, atherosclerosis and non-alcoholic steatohepatitis[1][2 ][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Salsalate | 99.61% | Salsalate is a potent antirheumatic drug with oral activity that reduces irritation during gastric absorption and avoids direct inhibition of cyclooxygenase. Salsalate not only has significant anti-inflammatory effects, but also reduces blood sugar levels, improves insulin resistance, and reduces the expression of cytokines. Salsalate can protect mice from metabolic disorders caused by high-fat diet and effectively improve the symptoms of type 2 diabetes, atherosclerosis and non-alcoholic steatohepatitis[2 ]. | ||||||||||||||||||||
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Salsalate (Standard) | ≥98% | Salsalate (Standard) is the analytical standard of Salsalate. This product is intended for research and analytical applications. Salsalate, a non-acetylated salicylate, is an effective antirheumatic agent that bypasses gastric absorption and also avoids cyclooxygenase inhibition. Salsalate has anti-inflammatory activity and reduces glucose levels, insulin resistance, and cytokine expression. Salsalate can be used in the research of type 2 diabetes. | ||||||||||||||||||||
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- [1]. Emily A Day, et al. Salsalate reduces atherosclerosis through AMPKβ1 in mice.Mol Metab.2021 Nov:53:101321. [Content Brief]
- [3]. Wen Liang, et al. Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes. Br J Pharmacol. 2015 Nov;172(22):5293-305. [Content Brief]
- [4]. Murthy SN, et al. Effects of salsalate therapy on recovery from vascular injury in female Zucker fatty rats. Diabetes. 2010;59(12):3240-3246. [Content Brief]
- [5]. Scheiman JM, et al. Gastroduodenal mucosal damage with salsalate versus aspirin: results of experimental models and endoscopic studies in humans. Semin Arthritis Rheum. 1990;20(2):121-127. [Content Brief]
- [6]. González F, et al. Salicylate administration suppresses the inflammatory response to nutrients and improves ovarian function in polycystic ovary syndrome. Am J Physiol Endocrinol Metab. 2020;319(4):E744-E752. [Content Brief]
Keywords
