552-94-3
552-94-3
Chemical Structure
Salsalate
Synonym(s): Salicylsalicylic acid; Disalicylic acid
- CAS. Nr.: 552-94-3
- Formula:C14H10O5
- Molecular Weight:258.23
IUPAC Name: 2-((2-hydroxybenzoyl)oxy)benzoic acid
InChIKey: WVYADZUPLLSGPU-UHFFFAOYSA-N
SMILES: O=C(OC1=CC=CC=C1C(O)=O)C2=CC=CC=C2O
Biological Activity: Salsalate is a potent antirheumatic drug with oral activity that reduces irritation during gastric absorption and avoids direct inhibition of cyclooxygenase. Salsalate not only has significant anti-inflammatory effects, but also reduces blood sugar levels, improves insulin resistance, and reduces the expression of cytokines. Salsalate can protect mice from metabolic disorders caused by high-fat diet and effectively improve the symptoms of type 2 diabetes, atherosclerosis and non-alcoholic steatohepatitis[1][2 ][3][4][5][6].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Salsalate | 99.61% | Salsalate is a potent antirheumatic drug with oral activity that reduces irritation during gastric absorption and avoids direct inhibition of cyclooxygenase. Salsalate not only has significant anti-inflammatory effects, but also reduces blood sugar levels, improves insulin resistance, and reduces the expression of cytokines. Salsalate can protect mice from metabolic disorders caused by high-fat diet and effectively improve the symptoms of type 2 diabetes, atherosclerosis and non-alcoholic steatohepatitis[2 ]. | ||||||||||||||||||||
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Salsalate (Standard) | 99.23% | Salsalate (Standard) is the analytical standard of Salsalate. This product is intended for research and analytical applications. Salsalate, a non-acetylated salicylate, is an effective antirheumatic agent that bypasses gastric absorption and also avoids cyclooxygenase inhibition. Salsalate has anti-inflammatory activity and reduces glucose levels, insulin resistance, and cytokine expression. Salsalate can be used in the research of type 2 diabetes. | ||||||||||||||||||||
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ML-097 | 99.90% | ML-097 (CID-2160985) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, and Rab7. | ||||||||||||||||||||
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Tenosal | Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties. | |||||||||||||||||||||
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Tri-Salicylic acid | 98.01% | Tri-Salicylic acid (Compound III) is a compound with similar properties to salicylic acid. Tri-Salicylic acid can be used in the research of inflammation, obesity, diabetes, and cardiovascular disease. | ||||||||||||||||||||
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Guacetisal (Standard) | ≥98% | Guacetisal (Standard) is the analytical standard of Guacetisal. This product is intended for research and analytical applications. Guacetisal suppresses the synthesis of prostaglandin PG. Guacetisal is obtained from the esterification of acetylsalicylic acid with guaiacol which has the potential for chronic bronchitis treatment extracted from patent CN 106866420 A. | ||||||||||||||||||||
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Phenyl salicylate (Standard) | 99.98% | Phenyl salicylate (Standard) is the analytical standard of Phenyl salicylate (HY-B1731). This product is intended for research and analytical applications. Phenyl salicylate is an ester derivative of Salicylic acid (HY-B0167) that exhibits no antimycobacterial activity. Phenyl salicylate can cross-sensitize with Resorcinol monobenzoate. Phenyl salicylate is used in research related to contact dermatitis. | ||||||||||||||||||||
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2-Benzyloxybenzoic acid | 2-Benzyloxybenzoic acid is a Benzyloxy-benzene (HY-W022039) derivative. | |||||||||||||||||||||
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Methylenedisalicylic acid(mixture of isomers) | Methylenedisalicylic acid(mixture of isomers) (3,3'-Methanediylbis(2-hydroxybenzoic acid)) is a metal-organic framework (MOF). | |||||||||||||||||||||
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Acetylsalicylsalicylic acid | 99.24% | Acetylsalicylsalicylic acid exhibits immunogenicity that induces contact sensitivity and causes skin erythema and slight edema in guinea pigs. | ||||||||||||||||||||
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2,2'-Oxydibenzoic acid | 2,2'-Oxydibenzoic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
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Acetaminosalol | Acetaminosalol, a merged ester NSAID–APAP hybrid, is a metabolite of Benorylate (HY-107795) and a prodrug of Acetaminophen (HY-66005) and Aalicylic acid (HY-B0167). Acetaminosalol can be used for the research of acute rheumatism. | |||||||||||||||||||||
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References
- [1]. Emily A Day, et al. Salsalate reduces atherosclerosis through AMPKβ1 in mice.Mol Metab.2021 Nov:53:101321. [Content Brief]
- [3]. Wen Liang, et al. Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes. Br J Pharmacol. 2015 Nov;172(22):5293-305. [Content Brief]
- [4]. Murthy SN, et al. Effects of salsalate therapy on recovery from vascular injury in female Zucker fatty rats. Diabetes. 2010;59(12):3240-3246. [Content Brief]
- [5]. Scheiman JM, et al. Gastroduodenal mucosal damage with salsalate versus aspirin: results of experimental models and endoscopic studies in humans. Semin Arthritis Rheum. 1990;20(2):121-127. [Content Brief]
- [6]. González F, et al. Salicylate administration suppresses the inflammatory response to nutrients and improves ovarian function in polycystic ovary syndrome. Am J Physiol Endocrinol Metab. 2020;319(4):E744-E752. [Content Brief]
