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CC260 

Cat. No.: HY-139188
Handling Instructions

CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research.

For research use only. We do not sell to patients.

CC260 Chemical Structure

CC260 Chemical Structure

CAS No. : 2411088-26-9

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Description

CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1].

IC50 & Target

Ki: 40 nM (PI5P4Kα) and 30 nM (PI5P4Kβ)[1]

In Vitro

In cultured C2C12 myotubes, CC260 (20 μM) enhances Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppresses S6K phosphorylation (Thr-389) by mTORC1[1].
CC260 (2.5 μM, 5 μM, 10 μM, 20 μM) significantly increases phosphorylation of acetyl-CoA carboxylase (ACC) in a dose-dependent manner[1].
CC260 treatment reduces the ability of BT474 cells to survive serum starvation, which could be rescued by expressing the PI5P4Kβ refractory mutant[1].
In BT474 cells, CC260 treatment causes an increase in glycolytic ATP production[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

490.43

Formula

C₂₄H₂₉Cl₂N₅O₂

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CC260
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HY-139188
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