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Cat. No.: HY-168515

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CDK9-IN-35

CDK9-IN-35 (compound 10j) is an inhibitor of CDK9/Cyclin T1 with an IC₅₀ value of 10.2 nM and against the HCT-116 cell line with an IC₅₀ value of 20 nM.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₄ClFN₄O₄S
Molecular Weight:543.01

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

CDK9-IN-35 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

CDK9-IN-35 (compound 10j) is an inhibitor of CDK9/Cyclin T1 with an IC₅₀ value of 10.2 nM and against the HCT-116 cell line with an IC₅₀ value of 20 nM^[1].

All CDK Isoforms :

Chemical Information

Molecular Weight 543.01
Formula C₂₆H₂₄ClFN₄O₄S
SMILES

COC1=C(N=C(N=C1)NC2=CC=C(C(Cl)=C2)OCC3=CC=CC(F)=C3)NCC4=CC=C(C=C4)S(C)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gopalakrishnan Venkatesan, et al. Design, synthesis, molecular modeling and evaluation of 2,4-diaminopyrimidine analogues as promising colorectal cancer drugs. Bioorg Chem. 2024 Sep 29:153:107854. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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CDK9-IN-35

All CDK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CDK9-IN-35 Related Classifications

HY-168515 Related Classifications