1. Anti-infection
  2. Bacterial
  3. Cefaloglycin

Cefaloglycin (Synonyms: Cephaloglycin)

Cat. No.: HY-16137
Handling Instructions

Cefaloglycin (Cephaloglycin) is an orally active nephrotoxic β-lactam cephalosporin antibiotic with antibacterial activity. Cefaloglycin is activity against Gram-Positive cocci other than enterococci. Cefaloglycin is toxic to mitochondrial substrate uptake and respiration.

For research use only. We do not sell to patients.

Cefaloglycin Chemical Structure

Cefaloglycin Chemical Structure

CAS No. : 3577-01-3

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Description

Cefaloglycin (Cephaloglycin) is an orally active nephrotoxic β-lactam cephalosporin antibiotic with antibacterial activity. Cefaloglycin is activity against Gram-Positive cocci other than enterococci. Cefaloglycin is toxic to mitochondrial substrate uptake and respiration[1][2][3].

IC50 & Target

Gram-Positive cocci[2]

In Vitro

Cefaclor to be comparable to Cephaloglycin in terms of in vitro activity against S. pyogenes and somewhat superior to Cephalexin[2].

In Vivo

Respiration with and the uptake of succinate and ADP are measured in rabbit renal cortical mitochondria exposed for 2 to 6 h to 300 to 3,000 µg of Cefaloglycin (Cephaloglycin) per mL and then washed to remove the antibiotic. Cefaloglycin (Cephaloglycin) irreversibly reduces both respiration and succinate uptake. The pattern of in vitro injury of Cefaloglycin to mitochondrial substrate uptake and respiration evolves in a time-dependent and concentration-dependent manner[1].

Molecular Weight

405.42

Formula

C₁₈H₁₉N₃O₆S

CAS No.

3577-01-3

SMILES

OC(C(N(C1=O)[[email protected]@](SC2)([H])[[email protected]@H]1NC([[email protected]@H](C3=CC=CC=C3)N)=O)=C2COC(C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CefaloglycinCephaloglycinBacterialβ-lactamcephalosporinantibioticmitochondrialrespirationsuccinatenephrotoxicantibacterialInhibitorinhibitorinhibit

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Cefaloglycin
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HY-16137
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