5-Fluoroindole
Based on 1 Customer Validation
5-Fluoroindole is an orally active fluorinated indole derivative and antibacterial agent. 5-Fluoroindole induces ROS accumulation and triggers Apoptosis. 5-Fluoroindole inhibits the growth of pan-susceptible Mycobacterium tuberculosis (Mtb) H37Rv strains. 5-Fluoroindole has significant bactericidal activity against Pseudomonas syringae pv. actinidiae (Psa) with an EC50 of 15.34 μg/mL. 5-Fluoroindole introduces fluorine labeling for protein research. 5-Fluoroindole can be used in the study of tuberculosis and kiwifruit bacterial canker.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.88%
- CAS. Nr.: 399-52-0
- Formel: C8H6FN
- Molecular Weight:135.14
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Speicherung:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-W007613
7-Fluoro-1H-indole
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HY-21194
Perfluorohexanoic acid
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HY-W007549
5-Fluoroisatin
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HY-21190
Perfluorobutylsulfonyl fluoride
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HY-W015229
3-Indolepropionic acid
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HY-40161
Indole-3-carboxylic acid
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HY-W007376
Indole-3-carboxaldehyde
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HY-I0096
Indole-2-carboxylic acid
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HY-W007376R
Indole-3-carboxaldehyde (Standard)
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HY-W015229R
3-Indolepropionic acid (Standard)
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HY-40161R
Indole-3-carboxylic acid (Standard)
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HY-30236
5-Bromoindole
Biologische Aktivität
5-Fluoroindole (4.7-29.1 μM) inhibits the growth of pansensitive Mycobacterium tuberculosis (Mtb) H37Rv strain and drug-resistant clinical isolates[1].
5-Fluoroindole has high metabolic stability (Clint 9.0 mL/min/kg) in rat liver microsomes[1].
5-Fluoroindole exhibits significant bactericidal activity against Pseudomonas syringae pv. actinidiae (Psa), with an EC50 of 15.34 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 399-52-0
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Appearance Solid
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Molecular Weight 135.14
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Formel C8H6FN
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Color White to light brown
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SMILES
FC1=CC=C2NC=CC2=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (739.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (18.50 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (18.50 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Neves CE, et al., 5-Fluoroindole Reduces the Bacterial Burden in a Murine Model of Mycobacterium tuberculosis Infection. ACS Omega. 2024 Jul 16;9(30):32969-32979. [Content Brief]
[2]. Zhang C, et al. 5-Fluoroindole Inhibits Its Putative Target Methionine Synthase and Pseudomonas syringae pv. actinidiae Virulence. J Agric Food Chem. 2025 Jul 2;73(26):16193-16204. [Content Brief]
[3]. Pan B, et al. Fluorine-19 labeling of the tryptophan residues in the G protein-coupled receptor NK1R using the 5-fluoroindole precursor in Pichia pastoris expression. J Biomol NMR. 2024 Sep;78(3):133-138. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.3997 mL | 36.9987 mL | 73.9973 mL | 184.9933 mL |
| 5 mM | 1.4799 mL | 7.3997 mL | 14.7995 mL | 36.9987 mL | |
| 10 mM | 0.7400 mL | 3.6999 mL | 7.3997 mL | 18.4993 mL | |
| 15 mM | 0.4933 mL | 2.4666 mL | 4.9332 mL | 12.3329 mL | |
| 20 mM | 0.3700 mL | 1.8499 mL | 3.6999 mL | 9.2497 mL | |
| 25 mM | 0.2960 mL | 1.4799 mL | 2.9599 mL | 7.3997 mL | |
| 30 mM | 0.2467 mL | 1.2333 mL | 2.4666 mL | 6.1664 mL | |
| 40 mM | 0.1850 mL | 0.9250 mL | 1.8499 mL | 4.6248 mL | |
| 50 mM | 0.1480 mL | 0.7400 mL | 1.4799 mL | 3.6999 mL | |
| 60 mM | 0.1233 mL | 0.6166 mL | 1.2333 mL | 3.0832 mL | |
| 80 mM | 0.0925 mL | 0.4625 mL | 0.9250 mL | 2.3124 mL | |
| 100 mM | 0.0740 mL | 0.3700 mL | 0.7400 mL | 1.8499 mL |
5-Fluoroindole Related Classifications
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