Art. -Nr.: HY-114395

NVS-ZP7-4

8 Cited Publications

Kundenbewertung

Based on 8 publication(s) in Google Scholar

NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7) and indicates ER zinc levels. ZIP7 is an active molecular node in the Notch pathway and mediates ferroptosis. NVS-ZP7-4 induces ER stress and exerts a certain ferroptosis-inhibiting effect, reduces Erastin (HY-15763)-induced cell death.

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Reinheit: 98.85%
CAS. Nr.: 2349367-89-9
Formel: C₂₈H₂₈FN₅OS
Molecular Weight:501.62

Speicherung:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

NVS-ZP7-4 Chemical Structure

CAS. Nr.: 2349367-89-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (8)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

ZIP7^[1].

In Vitro

NVS-ZP7-4 increases ER zinc levels, suggesting functional modulation of ZIP7^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2349367-89-9
Appearance Solid
Molecular Weight 501.62
Formel C₂₈H₂₈FN₅OS
Color Light yellow to yellow
SMILES

O=C(NC12CCN(C[C@@H](NC3=NC4=CC=C(F)C=C4S3)CC5=CC=CC=C5)CC2)NC6=C1C=CC=C6
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (8)

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Journal Impact Factor

Nat Commun

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]

2026 Feb 12;17(1):1214. PMID: 41680175
J Adv Res

A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function. [Abstract]

2025 Feb 13:S2090-1232(25)00077-3. PMID: 39955018
Cell Death Dis

Zinc transporter ZIP7 is a novel determinant of ferroptosis. [Abstract]

2021 Feb 19;12(2):198. PMID: 33608508
Food Chem X

Preparation, characterization, assembly, and stability of walnut peptide - zinc complexes and its ability to promote zinc transport in Caco-2 cells. [Abstract]

2025 Sep 16:31:103046. PMID: 41036460
Sci Total Environ

ACSL4-mediated ZIP7-VDAC3 interaction regulates endoplasmic reticulum-mitochondria iron transfer in hepatocytes under PFOS exposure. [Abstract]

2024 Nov 25:957:177679. PMID: 39579909
Int J Mol Sci

Delineating Zinc Influx Mechanisms during Platelet Activation. [Abstract]

2023 Jul 20;24(14):11689. PMID: 37511448
Sci Rep

NVS-ZP7-4 inhibits hepatocellular carcinoma tumorigenesis and promotes apoptosis via PI3K/AKT signaling. [Abstract]

2023 Jul 21;13(1):11795. PMID: 37479837
PLoS Genet

Human genetic adaptation related to cellular zinc homeostasis. [Abstract]

2023 Sep 25;19(9):e1010950. PMID: 37747921

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 125 mg/mL (249.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9935 mL

9.9677 mL

19.9354 mL

5 mM

0.3987 mL

1.9935 mL

3.9871 mL

10 mM

0.1994 mL

0.9968 mL

1.9935 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188. [Content Brief]

[2]. Chen PH, et al. Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell Death Dis. 2021 Feb 19;12(2):198. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9935 mL	9.9677 mL	19.9354 mL	49.8385 mL
	5 mM	0.3987 mL	1.9935 mL	3.9871 mL	9.9677 mL
	10 mM	0.1994 mL	0.9968 mL	1.9935 mL	4.9839 mL
	15 mM	0.1329 mL	0.6645 mL	1.3290 mL	3.3226 mL
	20 mM	0.0997 mL	0.4984 mL	0.9968 mL	2.4919 mL
	25 mM	0.0797 mL	0.3987 mL	0.7974 mL	1.9935 mL
	30 mM	0.0665 mL	0.3323 mL	0.6645 mL	1.6613 mL
	40 mM	0.0498 mL	0.2492 mL	0.4984 mL	1.2460 mL
	50 mM	0.0399 mL	0.1994 mL	0.3987 mL	0.9968 mL
	60 mM	0.0332 mL	0.1661 mL	0.3323 mL	0.8306 mL
	80 mM	0.0249 mL	0.1246 mL	0.2492 mL	0.6230 mL
	100 mM	0.0199 mL	0.0997 mL	0.1994 mL	0.4984 mL

Keywords

NVS-ZP7-4

8 Cited Publications

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NVS-ZP7-4

Immunology/Inflammation Compound Library

Membrane Transporter/Ion Channel Compound Library

Ferroptosis Compound Library

Endoplasmic Reticulum Stress Compound Library

Chemical Probe Library

Heterocyclic Compound Library

Cell Death Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) NVS-ZP7-4

Biologische Aktivität

Chemical Information

Publications (8)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

NVS-ZP7-4

Immunology/Inflammation Compound Library

Membrane Transporter/Ion Channel Compound Library

Ferroptosis Compound Library

Endoplasmic Reticulum Stress Compound Library

Chemical Probe Library

Heterocyclic Compound Library

Cell Death Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) NVS-ZP7-4

Biologische Aktivität

Chemical Information

Publications (8)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

NVS-ZP7-4 Related Classifications

Art. -Nr.: HY-114395