Absinthin
Based on 1 publication(s) in Google Scholar
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46.
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- Reinheit: 98.0%
- CAS. Nr.: 1362-42-1
- Formel: C30H40O6
- Molecular Weight:496.64
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Speicherung:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Absinthin
More
Biologische Aktivität
Absinthin (10 μM, 60 s) inhibits histamine-induced Ca2+ increases via hTAS2R46 in airway smooth muscle (ASM) cells[3].
Absinthin (1 and 10 μM, 1 h or 18 h) shows antioxidant activity, and inhibits PMA (HY-18739) induced superoxide anion production (1 h) and iNOS expression (18 h) in BEAS-2B cells[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS-induced acute lung injury in mice[4]
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Dosage:20, 40, 80mg/kg
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Administration:p.o.
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Result:Reduced inflammatory cell infiltration and improved lung architecture.
Reduced MPO activity, infiltration of neutrophils, lung tissue wet-to-dry ratio.
Reduced the secretion of proinflammatory cytokines and chemokines (TNF-α, IL-1β, IL-6 , and MIP-1α).
Chemical Information
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CAS. Nr. 1362-42-1
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Appearance Solid
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Molecular Weight 496.64
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Formel C30H40O6
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Color White to off-white
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SMILES
CC1=C[C@@]2([H])[C@]3([H])[C@]1([C@](OC4=O)([H])[C@@]([C@@H]4C)([H])CC[C@@]3(O)C)[C@]5([H])[C@@]2([H])[C@]([C@]6(O)C)([H])C([C@](OC7=O)([H])[C@@]([C@@H]7C)([H])CC6)=C5C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Histol Histopathol
The Kininogen 1/bradykinin receptor B2 system serves as a key molecular response of vancomycin-induced nephrotoxicity and may be a potential target of absinthin. [Abstract]2026 May 5:25085. PMID: 42084235
Lösungsmittel & Löslichkeit
DMSO : 5 mg/mL (10.07 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Zhang W, et al. Total synthesis of absinthin. J Am Chem Soc. 2005 Jan 12;127(1):18-9. [Content Brief]
[2]. Lachenmeier DW, et al. Absinthe--a review. Crit Rev Food Sci Nutr. 2006;46(5):365-77. [Content Brief]
[3]. Talmon M, et al. Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca2+-shuttling event. J Biol Chem. 2019 Aug 16;294(33):12472-12482. [Content Brief]
[4]. Guo N, et al. Absinthin attenuates LPS-induced ALI through MIP-1α-mediated inflammatory cell infiltration. Exp Lung Res. 2015;41(9):514-24. [Content Brief]
[5]. Talmon M, et al. Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells. J Nat Prod. 2020 Jun 26;83(6):1740-1750. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0135 mL | 10.0677 mL | 20.1353 mL | 50.3383 mL |
| 5 mM | 0.4027 mL | 2.0135 mL | 4.0271 mL | 10.0677 mL | |
| 10 mM | 0.2014 mL | 1.0068 mL | 2.0135 mL | 5.0338 mL |
Absinthin Related Classifications
HY-N0742 Related Classifications
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