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Art. -Nr.: HY-10711

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ALX-5407

(Synonyms: (R)-NFPS)

ALX-5407 ((R)-NFPS) is a selective and orally active glycine transporter GlyT1 inhibitor with an IC₅₀ value of 3 nM. ALX-5407 can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 571147-18-7
Formel: C₂₄H₂₄FNO₃
Molecular Weight:393.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

ALX-5407 Chemical Structure

CAS. Nr.: 571147-18-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle GlyT Isoform-spezifische Produkte anzeigen :

GlyT1
GlyT2

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	IC₅₀	3 nM Compound: ALX-5407	Inhibition of [3H]glycine uptake at rat glycine transporter 1 expressed in african green monkey COS7 cells Inhibition of [3H]glycine uptake at rat glycine transporter 1 expressed in african green monkey COS7 cells	[PMID: 19013063]
JAR	IC₅₀	0.39 nM Compound: ALX5407	Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting	[PMID: 21975065]
T98G	IC₅₀	4.8 nM Compound: ALX-5407	Inhibition of [3H]glycine uptake in human T98G cells Inhibition of [3H]glycine uptake in human T98G cells	[PMID: 19013063]

In Vitro

ALX-5407 (0-1 mM) GlyT1- or GlyT2-dependently inhibits glycine transport and blocks [³H]glycine uptake in rat brain and QT6-1C cells with an IC₅₀ value of 3 nM^[1].
ALX-5407 (50 nM) shows slow dissociation kinetics in QT6-1C cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ALX-5407 (1 and 10 mg/kg; oral administration, once) increases free glycine levels in rat prefrontal cortex^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 571147-18-7
Molecular Weight 393.45
Formel C₂₄H₂₄FNO₃
SMILES

OC(CN(C)CC[C@H](C1=CC=C(C=C1)F)OC2=CC=C(C3=CC=CC=C3)C=C2)=O
Synonyms

(R)-NFPS
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Atkinson BN, et al. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60(6):1414-20. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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ALX-5407

Alle GlyT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

ALX-5407 Related Classifications

HY-10711 Related Classifications