AO-022
AO-022 is a potent TALDO1 allosteric inhibitor. AO-022 decreases the expression of vimentin and snail. AO-022 shows antiproliferative activity and antitumor activity. AO-022 has the potential for the research of breast cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C21H16ClNO4S
- Molecular Weight:413.87
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
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Biologische Aktivität
TALDO1[1]
AO-022 (5, 10, 20, 40, 80 µM; 24 h) inhibits cell viability in a dose-dependent manner in MDA-MB-231 cells[1].
AO-022 (0, 2.5,5, 10, 20 µM; 24 h) decreases the protein expression of vimentin and snail in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:0, 2.5,5, 10, 20 µM
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Incubation Time:24 h
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Result:Inhibited the protein expression of vimentin and snail in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old female nude mice (MDA-MB-231 cells)[1]
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Dosage:50 mg/kg
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Administration:I.p.; every other day for fourteen days
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Result:Significantly reduced tumor volume and tumor weight.
Chemical Information
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Molecular Weight 413.87
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Formel C21H16ClNO4S
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SMILES
O=C1N(CC2=CC=CS2)C3=C(C=C(Cl)C=C3)[C@]1(O)CC(C4=CC=CC=C4O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Xu G, Huang R, Wumaier R, Lyu J, Huang M, Zhang Y, Chen Q, Liu W, Tao M, Li J, Tao Z, Yu B, Xu E, Wang L, Yu G, Gires O, Zhou L, Zhu W, Ding C, Wang H. Proteomic Profiling of Serum Extracellular Vesicles Identifies Diagnostic Signatures and Therapeutic Targets in Breast Cancer. Cancer Res. 2024 Jun 20. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AO-022 Related Classifications
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