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Art. -Nr.: HY-179036

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APG-7

APG-7 binds to the TLR4/MD-2 interface, thereby inhibiting NO production (IC₅₀ of 24.2 μg/mL). APG-7 is an Apigenin (HY-N1201) derivative. APG-7 has low toxicity to the 3T3 fibroblast cell line. APG-7 can be used for the study of oxidative stress and inflammation.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₀H₂₆O₁₂
Molecular Weight:578.52

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

APG-7 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

TLR4

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen :

In Vitro

APG-7 (25 μg/mL) inhibits the formation of superoxide anion with 29.06% inhibition^[1].
APG-7 (0.1-100 μg/mL; 48 h) showed no toxicity at ∼25 μg/mL on fibroblast cells^[1].
In-silico anti-cancer activity analysis reveals that APG-7 displays anti-cancer activity for B-lymphoblastic cells, colon adenocarcinoma, non-small cell lung carcinoma, and metastatic melanoma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

3T3 fibroblast cells
Concentration:

100 μg/mL, 10 μg/mL, 1.0 μg/mL, 0.1 μg/mL
Incubation Time:

48 h
Result:

Moderately suppressed the production of free radicals. Did not show toxicity up to concentration of 25 μg/mL.

Chemical Information

Molecular Weight 578.52
Formel C₃₀H₂₆O₁₂
SMILES

O[C@@H]1[C@@H](OC2=CC=C(C=C2)C3=CC(C4=C(C=C(C=C4O3)O)O)=O)O[C@@H](COC(/C=C/C5=CC=C(C=C5)O)=O)[C@H](O)[C@@H]1O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Soomro S, et al. Apigenin and its derivative modulate nitric oxide production and interfere with TLR4-M2: In-vitro and in-silico insights. Bioorg Chem. Published online October 4, 2025. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
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Reinheit:
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APG-7

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

APG-7 Related Classifications

HY-179036 Related Classifications