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Art. -Nr.: HY-103265A

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ARL67156

(Synonyms: FPL 67156)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

ARL67156 is an inhibitor of ecto-ATPase. ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with K_is of 11, 18 and 12 μM, respectively.

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CAS. Nr.: 160928-38-1
Formel: C₁₅H₂₄Br₂N₅O₁₂P₃
Molecular Weight:719.11

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

ARL67156 Chemical Structure

CAS. Nr.: 160928-38-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (3)
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Biologische Aktivität

Beschreibung

ARL67156 is an inhibitor of ecto-ATPase. ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with K_is of 11, 18 and 12 μM, respectively^[1].

IC₅₀ & Target

Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)^[1]

In Vitro

ARL67156 is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 160928-38-1
Molecular Weight 719.11
Formel C₁₅H₂₄Br₂N₅O₁₂P₃
SMILES

O[C@H]1[C@@H](O[C@H](COP(OP(C(Br)(Br)P(O)(O)=O)(O)=O)(O)=O)[C@H]1O)N2C3=C(C(N(CC)CC)=NC=N3)N=C2
Synonyms

FPL 67156
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Neuron

A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo. [Abstract]

2022 Mar 2;110(5):770-782.e5. PMID: 34942116
Front Immunol

CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation. [Abstract]

2022 Oct 4:13:946871. PMID: 36268017
Curr Eye Res

Integrated Spatiotemporal and Correlative Analysis of ATP-Related Signaling Components in Lens Development. [Abstract]

2026 Apr;51(4):359-373. PMID: 41310968

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lévesque SA, et al. Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases. Br J Pharmacol. 2007 Sep;152(1):141-50. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

ARL67156

3 Cited Publications

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Chemical Information
Publications (3)
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ARL67156

Publications Citing Use of MedChemExpress (MCE) ARL67156

Biologische Aktivität

Chemical Information

Publications (3)

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ARL67156 Related Classifications

HY-103265A Related Classifications