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Art. -Nr.: HY-182681

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AV-9606-129

AV-9606-129 is a USP28 inhibitor with an IC₅₀ of < 1 μM. AV-9606-129 inhibits the enzymatic activity of USP28 and downregulates the protein levels of c-Myc and c-Myb. AV-9606-129 can be used in cancer research.

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CAS. Nr.: 783309-48-8
Formel: C₁₇H₁₈Cl₂N₂O₃S
Molecular Weight:401.31

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AV-9606-129 Chemical Structure

CAS. Nr.: 783309-48-8

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Biologische Aktivität

Beschreibung

Alle Deubiquitinase Isoform-spezifische Produkte anzeigen :

In Vitro

AV-9606-129 (30 min; 30 min) potently inhibits purified recombinant USP28 protein with an IC₅₀ of < 1 μM^[1].
AV-9606-129 (100 μM) modulates the activity of a subset of 41 tested purified deubiquitinase enzymes^[1].
AV-9606-129 (1 h) dose-dependently engages endogenous USP28 in K562 cell lysates, as demonstrated by reduced Ub-VME labeling of USP28^[1].
AV-9606-129 (25-100 μM) downregulates C-Myc and C-Myb protein levels in NOMO-1, K562, MOLM14, and MM1S human cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 783309-48-8
Molecular Weight 401.31
Formel C₁₇H₁₈Cl₂N₂O₃S
SMILES

O=C(CC1=CC=C(C(Cl)=C1)Cl)NC2=CC(S(=O)(N(C)C)=O)=CC=C2C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Buhrlage S. Substituted 3-amino-4-methylbenzenesulfonamides as small molecule inhibitors of ubiquitin-specific protease 28, WO, WO2022035804A1, 2022-02-17.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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AV-9606-129

Alle Deubiquitinase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

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AV-9606-129 Related Classifications

HY-182681 Related Classifications