AZD3147
Based on 1 publication(s) in Google Scholar
AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.93%
- CAS. Nr.: 1101810-02-9
- Formel: C24H31N5O4S2
- Molecular Weight:517.66
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AZD3147
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Biologische Aktivität
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mTORC1 |
mTORC2 |
AZD3147 (0-50 nM, 1 h) can alleviate fibroblast growth factor (FGF)-mediated cilia extension at concentrations above 1.5 nM in NIH3T3 cells[2].
AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly and IMR-32 with the IC50 values of 0.88 nM and 662.4 nM, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Parameter | Mouse | Dog |
| CL (mL/min/kg) | 78 | 16 |
| Vss (L/kg) | 2.3 | 2.2 |
| t1/2(h) | 0.9 | 1.9 |
| F% | 61 | 73 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1101810-02-9
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Appearance Solid
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Molecular Weight 517.66
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Formel C24H31N5O4S2
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Color Off-white to light yellow
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SMILES
O=S(C1(C2=NC(C3=CC=C(C=C3)NC(NCCO)=S)=NC(N4[C@H](COCC4)C)=C2)CC1)(C5CC5)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Comput Methods Biomech Biomed Engin
Harnessing glycolysis- and cholesterol synthesis-related genes for prognostic modeling in lung adenocarcinoma. [Abstract]2025 Sep 17:1-19. PMID: 40959888
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (241.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[2]. Michaela Kunova Bosakova, et al. Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies. Hum Mol Genet. 2018 Mar 15;27(6):1093-1105. [Content Brief]
[3]. Rebecca Waetzig, et al. Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells. Int J Med Sci. 2021 Jan 1;18(1):137-149. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9318 mL | 9.6588 mL | 19.3177 mL | 48.2942 mL |
| 5 mM | 0.3864 mL | 1.9318 mL | 3.8635 mL | 9.6588 mL | |
| 10 mM | 0.1932 mL | 0.9659 mL | 1.9318 mL | 4.8294 mL | |
| 15 mM | 0.1288 mL | 0.6439 mL | 1.2878 mL | 3.2196 mL | |
| 20 mM | 0.0966 mL | 0.4829 mL | 0.9659 mL | 2.4147 mL | |
| 25 mM | 0.0773 mL | 0.3864 mL | 0.7727 mL | 1.9318 mL | |
| 30 mM | 0.0644 mL | 0.3220 mL | 0.6439 mL | 1.6098 mL | |
| 40 mM | 0.0483 mL | 0.2415 mL | 0.4829 mL | 1.2074 mL | |
| 50 mM | 0.0386 mL | 0.1932 mL | 0.3864 mL | 0.9659 mL | |
| 60 mM | 0.0322 mL | 0.1610 mL | 0.3220 mL | 0.8049 mL | |
| 80 mM | 0.0241 mL | 0.1207 mL | 0.2415 mL | 0.6037 mL | |
| 100 mM | 0.0193 mL | 0.0966 mL | 0.1932 mL | 0.4829 mL |
AZD3147 Related Classifications
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