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Art. -Nr.: HY-183777

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B-007

B-007 is an AplnR agonist with G protein-biased signaling (EC₅₀ = 11.6 nM). B-007 activates the G protein pathway while abolishing β-arrestin1 and β-arrestin2 signaling. B-007 serves as a scaffold for development of G protein-biased apelin receptor agonists. B-007 can be used for the research of heart failure.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₂H₂₄F₅N₅O₇S
Molecular Weight:717.62

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

B-007 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
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Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Arrestin-2/β-Arrestin 1

Arrestin-3/β-Arrestin 2

Alle Arrestin Isoform-spezifische Produkte anzeigen :

In Vitro

B-007 potently activates the AplnR G protein pathway in cell systems expressing the Apelin receptor (AplnR), with an EC₅₀ of 11.6 nM and an E_max of 118.0%^[1].
B-007 completely fails to activate the β-arrestin1 or β-arrestin2 pathways of the AplnR in AplnR-expressing cell systems, thereby exhibiting prominent G protein-biased characteristics^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 717.62
Formel C₃₂H₂₄F₅N₅O₇S
SMILES

COC1=CC=CC(OC)=C1C2=NC(C(NS(C(C3=CC=CC=C3)COC(C4=C(F)C(F)=C(F)C(F)=C4F)=O)(=O)=O)=O)=NN2C5=CN=CC(C)=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Shen C, et al. Design, synthesis, and biological evaluation of 1H-1,2,4-triazole-3-carboxamides as apelin receptor agonists. Bioorganic & Medicinal Chemistry Letters. 2026;138:130685.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vitro
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B-007

Alle Arrestin Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

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B-007 Related Classifications

HY-183777 Related Classifications