Biotin sodium
Based on 29 publication(s) in Google Scholar
Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
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- CAS. Nr.: 56085-82-6
- Formel: C10H15N2NaO3S
- Molecular Weight:266.29
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Biotin sodium
More- Autophagy. 2026 Jun;22(6):1203-1220. [Abstract]
- Cell Discov. 2025 Sep 30;11(1):80. [Abstract]
- Mol Cell. 2023 Dec 7;83(23):4370-4385.e9. [Abstract]
- Theranostics. 2020 May 22;10(15):6839-6853. [Abstract]
- Acta Pharm Sin B. 2025 Apr;15(4):1974-1990. [Abstract]
- J Exp Clin Cancer Res. 2025 Nov 6;44(1):300. [Abstract]
- J Clin Invest. 2025 Mar 17;135(6):e185278. [Abstract]
- Adv Sci (Weinh). 2026 Mar 25:e21164. [Abstract]
- MedComm (2020). 2023 Apr 20;4(3):e255. [Abstract]
- Sci Adv. 2025 Dec 19;11(51).
- Cancer Biol Med. 2020 Aug 15;17(3):693-706. [Abstract]
- Pharmacol Res. 2022 Feb:176:106059. [Abstract]
- Int J Biol Sci. 2026 Apr 23;22(9):4784-4805. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Oncogene. 2026 Sep;45(33):3385-3400.
- Cell Rep. 2024 Aug 22;43(9):114662. [Abstract]
- Cell Rep. 2024 Mar 18;43(3):113930. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- Drug Deliv Transl Res. 2025 Oct 29. [Abstract]
- Cell Rep Methods. 2025 Jul 21;5(7):101103. [Abstract]
- Commun Biol. 2025 Jul 29;8(1):1127. [Abstract]
- Int J Mol Sci. 2024 Jan 4;25(1):670. [Abstract]
- Mol Nutr Food Res. 2026 Jan;70(1):e70371. [Abstract]
- ACS Chem Biol. 2020 Oct 16;15(10):2722-2730. [Abstract]
- Cell Biochem Biophys. 2025 Mar;83(1):1299-1312. [Abstract]
- PLoS One. 2025 Dec 18;20(12):e0339129. [Abstract]
- Res Sq. 2026 Apr 22.
- Res Sq. 2024 Nov 26.
- bioRxiv. 2024 July 19.
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Biologische Aktivität
Beschreibung
IC50 & Target
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Microbial Metabolite |
Human Endogenous Metabolite |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 56085-82-6
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Molecular Weight 266.29
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Formel C10H15N2NaO3S
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SMILES
O=C(O[Na])CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
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Synonyms
Vitamin B7 sodium; Vitamin H sodium; D-Biotin sodium
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (29)
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Journal Impact Factor
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Most Recent
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Autophagy
Regorafenib enhances anti-PDCD1/PD-1 therapeutic efficacy in colorectal cancer by promoting SQSTM1/p62-mediated CD274/PD-L1 degradation. [Abstract]2026 Jun;22(6):1203-1220. PMID: 41655134 -
Cell Discov
2025 Sep 30;11(1):80. PMID: 41027888
Biotin sodium purchased from MedChemExpress. Usage Cited in: Cell Discov. 2025 Sep 30;11(1):80. [Abstract]
Biotin (50 μM, 3 h). MDA-MB-231 cells were treated with indicated drugs for 3 h, and biotin was pulled down. Interacting proteins were stained with Coomassie brilliant blue and K48 polyUB was detected by western blotting
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Mol Cell
CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity. [Abstract]2023 Dec 7;83(23):4370-4385.e9. PMID: 38016475 -
Theranostics
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription. [Abstract]2020 May 22;10(15):6839-6853. PMID: 32550907
Biotin sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 May 22;10(15):6839-6853. [Abstract]
Immunoblot with anti-NCOR2, anti-ACACA, anti-FASN, anti-CAD, and anti-α-Tubulin antibodies of protein precipitated by streptavidin beads from MDA-MB-231 cell lysates in the presence of B-Emodin or Biotin (10 µM) for 5 h at 4 ℃ with rotation.
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Acta Pharm Sin B
Obesity-driven oleoylcarnitine accumulation in tumor microenvironment promotes breast cancer metastasis-like phenotype. [Abstract]2025 Apr;15(4):1974-1990. PMID: 40486851
Biotin sodium purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Apr;15(4):1974-1990. [Abstract]
Immunoblotting was performed to detect the presence of ADCY10 following co-incubation with cell lysate and subsequent precipitation of bound protein using streptavidin magnetic beads with either Bio-OLCarn or Biotin (20 mmol/L) for 12 h at 4 °C with continuous rotation.
Biotin sodium purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Apr;15(4):1974-1990. [Abstract]
Fluorescence intensity represents the colocalization of ADCY10 and Bio-OLCarn or Biotin (20 mmol/L) in HCC1806 cells overnight at 4 ℃; green: ADCY10, red: Bio-OLCarn.
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J Exp Clin Cancer Res
Dual CDK and MEK Inhibition potentiates CD8+ T cell-mediated antitumor immunity by inducing pyroptotic cell death in high-mutational head and neck cancer. [Abstract]2025 Nov 6;44(1):300. PMID: 41194215 -
J Clin Invest
Targeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS-mutant cancer models. [Abstract]2025 Mar 17;135(6):e185278. PMID: 40091835
Biotin sodium purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2025 Mar 17;135(6):e185278. [Abstract]
Biotin pull-down assay. SW620 cell protein lysates were incubated with biotin, biotin-RLY01 (B-RLY01; 10 μM), B-RLY01 (10 μM) + 100 μM RLY01 (10× molar excess), B-RLY01 (10 μM) + 200 μM RLY01 (20× molar excess) at room temperature for 3 hours by rotation.
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Adv Sci (Weinh)
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4-Mediated Acute Hepatitis. [Abstract]2026 Mar 25:e21164. PMID: 41881032 -
MedComm (2020)
Caffeic acid, but not ferulic acid, inhibits macrophage pyroptosis by directly blocking gasdermin D activation. [Abstract]2023 Apr 20;4(3):e255. PMID: 37090118 -
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Cancer Biol Med
An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway. [Abstract]2020 Aug 15;17(3):693-706. PMID: 32944400 -
Pharmacol Res
Brusatol has therapeutic efficacy in non-small cell lung cancer by targeting Skp1 to inhibit cancer growth and metastasis. [Abstract]2022 Feb:176:106059. PMID: 34998973 -
Int J Biol Sci
Tryptophan-Restricted Intermittent Diet Alleviates Estrogen Deficiency-Induced Osteoporosis via Regulating Coupling Effects of "Gut-Bone" Axis. [Abstract]2026 Apr 23;22(9):4784-4805. PMID: 42157925 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
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Cell Rep
CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism. [Abstract]2024 Aug 22;43(9):114662. PMID: 39178116 -
Cell Rep
PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA. [Abstract]2024 Mar 18;43(3):113930. PMID: 38507412 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Drug Deliv Transl Res
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [Abstract]2025 Oct 29. PMID: 41160380 -
Cell Rep Methods
2025 Jul 21;5(7):101103. PMID: 40645188 -
Commun Biol
Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway. [Abstract]2025 Jul 29;8(1):1127. PMID: 40730679 -
Int J Mol Sci
Isorhamnetin Regulates Programmed Death Ligand-1 Expression by Suppressing the EGFR-STAT3 Signaling Pathway in Canine Mammary Tumors. [Abstract]2024 Jan 4;25(1):670. PMID: 38203840 -
Mol Nutr Food Res
Salvianolic Acid A Protects Against Angiotensin II-Induced Hypertensive Kidney Disease by Targeting TLR4 and Inhibiting TLR4/Myd88/PI3K/AKT/NF-κB Pathway. [Abstract]2026 Jan;70(1):e70371. PMID: 41543314 -
ACS Chem Biol
Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. [Abstract]2020 Oct 16;15(10):2722-2730. PMID: 32865967 -
Cell Biochem Biophys
Amentoflavone Induces Ferroptosis to Alleviate Proliferation, Migration, Invasion and Inflammation in Rheumatoid Arthritis Fibroblast-like Synoviocytes by Inhibiting PIN1. [Abstract]2025 Mar;83(1):1299-1312. PMID: 39354278 -
PLoS One
Proteomic screening of TMEM43 binding partners identifies VDAC leading to mitochondrial dysfunction. [Abstract]2025 Dec 18;20(12):e0339129. PMID: 41411330 -
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Reinheit & Dokumentation
Verweise
[1]. Zempleni, et al. Biotin biochemistry and human requirements. J Nutr Biochem, 1999. 10(3): p. 128-38. [Content Brief]
[2]. Mock, D.M., Biotin status: which are valid indicators and how do we know? J Nutr, 1999. 129(2S Suppl): p. 498S-503S. [Content Brief]
[3]. Zempleni J, et al. Biotin. Biofactors. 2009 Jan-Feb;35(1):36-46. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Biotin sodium Related Classifications
HY-B0511A Related Classifications
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