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Art. -Nr.: HY-P992012

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CA1001

CA1001 is a small-molecule ZNF74 inhibitor and a peripherally restricted κ/δ dual opioid receptor agonist. CA1001 exhibits potent antitumor activity both in vitro and in vivo. CA1001, in combination with immune checkpoint inhibitors, significantly enhances tumor regression. CA1001 activates peripherally restricted κ/δ dual opioid receptors and exerts analgesic effects under conditions of inflammatory pain, neuropathic pain, and mechanical hyperalgesia. CA1001 can be used in research related to melanoma, mechanical hyperalgesia, neuropathic pain, and inflammatory arthritis pain.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CA1001 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Species Reactivity
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Species Reactivity

Human

Alle Opioid Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

CA1001 exhibits potent anti-tumor activity in melanoma cell lines^[1].
CA1001 exerts a synergistic effect when combined with immune checkpoint inhibitors, significantly enhancing tumor regression in melanoma cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CA1001 (1 mg/kg) attenuates acute responses in formalin-induced hyperalgesic mice^[2].
CA1001 (1-10 mg/kg, i.p., single administration) significantly reverses mechanical hyperalgesia at 10 mg/kg at 2 h and 4 h^[2].
CA1001 (1-10 mg/kg, i.p., single administration) significantly increases paw withdrawal threshold and reverses Complete Freund's adjuvant (CFA) (HY-153808)-induced mechanical hyperalgesia^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rat^[2]
Dosage:

1 mg/kg, 5 mg/kg, 10 mg/kg
Administration:

i.p., once
Result:

Significantly reversed mechanical hyperalgesia at 10 mg/kg at 2 h and 4 h.

Animal Model:

Rat^[2]
Dosage:

1 mg/kg, 5 mg/kg, 10 mg/k
Administration:

i.p., once
Result:

Significantly increased paw withdrawal threshold and reverses Complete Freund's adjuvant (CFA) (HY-153808)-induced mechanical hyperalgesia.

Gene ID

2811 [NCBI]

Accession

P07359

Target

CD42b/GP1BA

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Anwendung

ELISA, FACS, Functional assay

Chemical Information

SMILES

[CA1001]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Yeye Guo et al. ZNF74 as a novel therapeutic target in melanoma: Unveiling mechanisms and developing precision treatments.. J Clin Oncol 43, e21606-e21606(2025).

[2]. C. Hartrick, et al. The Efficacy of a Dual-Acting, Peripherally-Restricted Kappa/Delta Opioid Agonist (CA1001) in Neuropathic Pain in the Rat. Volume 20, Issue 4, Supplement, April 2019, Pages S38-S39

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Species Reactivity
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

CA1001

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

Alle Opioid Receptor Isoform-spezifische Produkte anzeigen