Casimiroin
Casimiroin is a QR2 and Aromatase inhibitor, with an IC50 of 54.1 μM against QR2 and an IC50 of 3.92 μM against aromatase. Casimiroin exhibits antimutagenic activity and inhibits DMBA (HY-W011845)-induced mutations in Salmonella typhimurium. Casimiroin suppresses DMBA-induced precancerous lesions in mouse mammary organ cultures. Casimiroin can be used in breast cancer-related research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 477-89-4
- Formel: C12H11NO4
- Molecular Weight:233.22
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Aromatase 3.92 μM (IC50) |
QR2 54.1 μM (IC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
85.81 μM
Compound: 1
|
Cytotoxicity against human LNCAP cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human LNCAP cells after 72 hrs by sulforhodamine B assay
|
[PMID: 19265439] |
| LNCaP | IC50 |
>85.81 μM
Compound: 1
|
Cytotoxicity against human LNCAP cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human LNCAP cells after 72 hrs by sulforhodamine B assay
|
[PMID: 19265439] |
| MCF7 | IC50 |
>85.81 μM
Compound: 1
|
Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 19265439] |
| MCF7 | IC50 |
85.81 μM
Compound: 1
|
Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 19265439] |
In Vitro
Casimiroin (0-20 μg/mL; 72 h) is not cytotoxic to Hepa 1c1c7, MCF7, LNCaP, or LU cell lines, with IC50 values >85.81 μM[1].
Casimiroin (range of concentrations; 10 min preincubation; 30 min enzyme incubation; 2 h post-quench incubation) inhibits recombinant aromatase (CYP19) with an IC50 of 3.92 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Hepa 1c1c7 (mouse liver), MCF7 (breast), LNCaP (prostate), LU (lung)
-
Concentration:0-20 μg/mL
-
Incubation Time:72 h
-
Result:Showed no significant cytotoxicity in any of the four cell lines, with IC50 values greater than 85.81 μM for all tested cell lines.
Chemical Information
-
CAS. Nr. 477-89-4
-
Molecular Weight 233.22
-
Formel C12H11NO4
-
SMILES
O=C1C=C(OC)C=2C=CC=3OCOC3C2N1C
-
Structure Classification
-
Initial Source
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Maiti A, et al. Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. Journal of medicinal chemistry. 2009 Apr 09;52(7):1873-84. [Content Brief]
[2]. Wang M, et al. Synthesis of carbon-11-labeled casimiroin analogues as new potential PET agents for imaging of quinone reductase 2 and aromatase expression in breast cancer. Steroids. 2010 Dec;75(12):967-73. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Casimiroin Related Classifications
HY-N11855 Related Classifications
Powered by Bioz