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Art. -Nr.: HY-117435

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CIDD 0067106

CIDD-0067106 is a selective mTORC1 pathway inhibitor targeting androgen receptor-positive (AR+) triple-negative breast cancer (TNBC). CIDD-0067106 demonstrates potent inhibition of AR+ TNBC cell lines with an GI₅₀ value of 0.8 μM. CIDD-0067106 is promising for research of AR+ TNBC.

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CAS. Nr.: 2151865-39-1
Formel: C₂₆H₂₉N₃O₄
Molecular Weight:447.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CIDD 0067106 Chemical Structure

CAS. Nr.: 2151865-39-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

mTORC1

Alle mTOR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A10	GI₅₀	35 μM Compound: 30	Cytotoxicity against rat A10 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against rat A10 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
BT-549	GI₅₀	40 μM Compound: 30	Cytotoxicity against human BT549 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human BT549 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
HCC1806	GI₅₀	30 μM Compound: 30	Cytotoxicity against human HCC1806 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human HCC1806 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
HCC1937	GI₅₀	35 μM Compound: 30	Cytotoxicity against human HCC1937 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human HCC1937 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
MDA-MB-231	GI₅₀	50 μM Compound: 30	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
MDA-MB-453	GI₅₀	0.8 μM Compound: 30	Cytotoxicity against human MDA-MB-453 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human MDA-MB-453 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
SUM185PE	GI₅₀	1.6 μM Compound: 30	Cytotoxicity against human SUM185PE cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human SUM185PE cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]

Chemical Information

CAS. Nr. 2151865-39-1
Molecular Weight 447.54
Formel C₂₆H₂₉N₃O₄
SMILES

C(C1=CC=C(C=2OC(=CN2)C3=CC=C(OCC=C(C)C)C=C3)N=C1)N4[C@H](C(OC)=O)CCC4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Robles AJ, et al. Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells. J Med Chem. 2017 Nov 22;60(22):9275-9289. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- IC₅₀ & Target
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CIDD 0067106

Alle mTOR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CIDD 0067106 Related Classifications

HY-117435 Related Classifications