Ciduvectamig
Based on 1 Customer Validation
Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 95.879%
- CAS. Nr.: 2412587-62-1
- Molecular Weight:143.771 kDa
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
IgG4-kappa-lambda
Human
CD3E & TMEFF2
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG4-kappa-lambda
ELISA, FACS, Functional assay
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Immobilized CD3D-CD3E Heterodimer Protein, Human (HEK293, His) (HY-P72726) can bind Ciduvectamig. The EC50 for this effect is 40.92 ng/mL. -
Immobilized TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) (HY-P700470) can bind Ciduvectamig. The EC50 for this effect is 297.4 ng/mL. -
Flow cytometric analysis of 1X106 FaDu cells with Ciduvectamig (HY-P990692, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black). -
Flow cytometric analysis of 1X106 Jurkat cells with Ciduvectamig (HY-P990692, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS. Nr. 2412587-62-1
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Appearance Liquid
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Molecular Weight 143.771 kDa
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Color Colorless to light yellow
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SMILES
[Ciduvectamig]
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Synonyms
JNJ-70218902; JNJ-902
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Versand
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (253 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Verweise
[1]. Ciduvectamig
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)