Coenzyme Q6
Coenzyme Q6 (Ubiquinone 30) is a redox-active benzoquinone lipid and mitochondrial electron carrier. Coenzyme Q6 can be used in research on MASLD, mitochondrial diseases, pneumococcal diseases, and steroid-resistant nephrotic syndrome with FSGS.
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- CAS. Nr.: 1065-31-2
- Formel: C39H58O4
- Molecular Weight:590.88
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Speicherung:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biologische Aktivität
Beschreibung
In Vitro
Coenzyme Q6 inhibits lipid peroxidation in ubiquinone-depleted bovine heart submitochondrial particles independently of vitamin E, and after reduction to ubiquinol, amplifies the antioxidant effect of vitamin E[2].
Coenzyme Q6 (50 μM; 1 h) is integrated into the plasma membrane of wild-type W303.1B and the coq3 mutant CC303.1, and increases ascorbate-stabilizing activity in both strains[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 1065-31-2
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Appearance Oil
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Molecular Weight 590.88
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Formel C39H58O4
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Color Colorless to light yellow
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SMILES
C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC(C(C(OC)=C1OC)=O)=C(C)C1=O
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Synonyms
Ubiquinone 30
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Structure Classification
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Initial Source
saccharomyces
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Protokoll
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ROS/oxidative-stress fluorescent staining
ROS/oxidative-stress fluorescent staining uses cell-permeant fluorogenic probes that become fluorescent after oxidation inside cells or tissues; commonly used examples include DCFH-DA/DCFDA for broad cellular oxidant detection, DHE for superoxide-related signal detection, MitoSOX for mitochondrial superoxide-related signal detection, and CellROX probes for oxidative-stress-associated fluorescence readouts. The assay detects probe oxidation rather than a single ROS species unless the probe and analysis method have been chemically validated for that species. DCFH-DA enters cells, is deacetylated by intracellular esterases to DCFH, and produces fluorescent DCF after oxidation, so the readout is used as an operational measure of total cellular oxidative stress rather than a species-specific ROS measurement. DHE and MitoSOX can report superoxide-related oxidation, but red fluorescence alone can include non-specific ethidium-like oxidation products; HPLC or optimized spectral approaches are
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
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- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Coenzyme Q6 Related Classifications
HY-N9610 Related Classifications
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Keywords
- Coenzyme Q6
- 1065-31-2
- Ubiquinone 30
- Coenzyme Q 6
- Coenzyme Q-6
- Ubiquinone30
- Ubiquinone-30
- Endogenous Metabolite
- metabolic dysfunction-associated steatotic liver disease
- de novo lipogenesis
- SIRT1
- pneumococcal disease
- lipid peroxidation
- mitochondrial bioenergetics
- Nrf2
- steroid-resistant nephrotic syndrome with FSGS
- gut microbial community composition
- PPARα
- Inhibitor
- inhibitor
- inhibit