Cyprolidol
Cyprolidol is an orally active inhibitor of acetylcholine receptor and histamine receptor with potential antidepressant activity. Cyprolidol inhibits acetylcholine-induced hypotensive response, histamine-induced systolic blood pressure decrease, tyramine-induced systolic blood pressure increase, serotonin-induced systolic blood pressure response in anesthetized animals, and bretylium-induced systolic blood pressure increase in anesthetized cats. Cyprolidol potentiates norepinephrine-induced systolic blood pressure increase, slightly potentiates epinephrine-induced systolic blood pressure increase, and enhances the anesthetic depth of barbiturates. Cyprolidol can be used in the research of depression.
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- CAS. Nr.: 4904-00-1
- Formel: C21H19NO
- Molecular Weight:301.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vivo
Cyprolidol (10 mg/kg; i.v.; single dose) produces a mean -34.16 mmHg systolic pressure fall in anesthetized dogs, while also potentiating norepinephrine and epinephrine pressor responses and inhibiting tyramine, histamine, acetylcholine, and serotonin responses[1].
Cyprolidol (10-30 mg/kg; i.v.; single dose) produces a biphasic systolic pressure response (-34.00 mmHg fall followed by +38.00 mmHg rise) in anesthetized cats, while also potentiating norepinephrine and epinephrine pressor responses, inhibiting tyramine, histamine, acetylcholine, serotonin, and bretylium responses, and at 30 mg/kg i.v. reversing bretylium-induced pressure rises to falls[1].
Cyprolidol (30 mg/kg; p.o.; daily; 14 days) does not alter normotensive systolic pressure in conscious dogs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 4904-00-1
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Molecular Weight 301.38
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Formel C21H19NO
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SMILES
OC(C1=CC=CC=C1)(C2=CC=CC=C2)[C@H]3[C@H](C4=CC=NC=C4)C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Protocol for Tail Suspension Test (TST)
The Tail Suspension Test is a mouse behavioral assay in which an animal is suspended by the tail in an inescapable position, causing alternating escape-directed activity and immobility; the main readout is immobility time, and antidepressant-like treatments generally reduce immobility compared with vehicle controls. The assay detects behavioral response to acute inescapable stress rather than a molecular event; immobility is interpreted as passive stress-coping behavior, while reduced immobility is used as a predictive screen for antidepressant-like activity, with important limitations related to strain, locomotor activity, and tail-climbing behavior.
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Protocol for Forced Swim Test (FST)
The Forced Swim Test is a rodent behavioral assay in which a mouse or rat is placed in an inescapable cylinder of water, and the main readout is the time spent immobile versus active escape-related behaviors such as swimming or climbing. Reduced immobility after treatment has historically been interpreted as antidepressant-like activity, but the assay should be interpreted as a behavioral response to acute inescapable stress rather than a complete model of human depression.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cyprolidol Related Classifications
HY-184374 Related Classifications
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