D-Trp-Aib
D-Trp-Aib is a dipeptide and amyloid-β inhibitor with a Kd of 29.6 nM. D-Trp-Aib triggers formation of non-toxic, non-β-sheet, amorphous amyloid β clusters from misfolded amyloid β monomers and toxic amyloid β oligomers, and reduces toxic amyloid β1-42 deposits. D-Trp-Aib inhibits amyloid fibril formation of α‑synuclein, IAPP and calcitonin. D-Trp-Aib can be used for the research of Alzheimer's disease.
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- CAS. Nr.: 1123071-24-8
- Formel: C15H19N3O3
- Molecular Weight:289.34
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
D-Trp-Aib (Compound 1) binds to Aβ1-42 with an Kd of 29.6 ± 1.7 nM[1].
D-Trp-Aib triggers the formation of larger, non-toxic amorphous and globular clusters from Aβ1-42[1].
D-Trp-Aib partially prevents Aβ1-42-induced membrane potential depolarization[1].
D-Trp-Aib (0.1 nM-1 μM; 90 min) reverses Aβ1-42-induced LTP deficits in mouse hippocampal slices[1].
D-Trp-Aib (molar ratio 1:10-1:30, 50 h) inhibits amyloid fibril formation of α‑synuclein, IAPP and calcitonin, and disassembles preformed amyloid fibrils[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
D-Trp-Aib (0.5-2.0%; eye drops; three times daily; 1 month) reduces toxic amyloid β1-42 deposits and associated complement component C3b inflammation in the retina of an aged AMD mouse model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (5-6 months old; age-related macular degeneration genetic model)[1]
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Dosage:0.5%; 2.0%
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Administration:eye drops; three times daily; 3 months
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Result:Caused a significant reduction in retinal amyloid β1-42 levels compared to vehicle-treated mice.
Produced a greater reduction in retinal amyloid β1-42 levels at 2.0% dose than at 0.5% dose.
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Animal Model:C57BL/6 (24 months old; aged age-related macular degeneration model)[1]
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Dosage:0.5%; 2.0%
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Administration:eye drops; three times daily; 1 month
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Result:Reduced thick, linear amyloid β1-42 deposits along the Bruch's membrane to isolated, non-toxic aggregates, with no amyloid β1-42 staining in the retinal pigment epithelium.
Induced a corresponding colocalized reduction in C3b (a marker of amyloid β-induced inflammation) compared to controls.
Chemical Information
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CAS. Nr. 1123071-24-8
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Molecular Weight 289.34
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Formel C15H19N3O3
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SMILES
C([C@H](C(NC(C(O)=O)(C)C)=O)N)C=1C=2C(NC1)=CC=CC2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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