DBCO-PEG5-NHS ester
Based on 1 publication(s) in Google Scholar
DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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- Reinheit: 96.77%
- CAS. Nr.: 2144395-59-3
- Formel: C36H43N3O11
- Molecular Weight:693.74
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Speicherung:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) DBCO-PEG5-NHS ester
MoreAlle ADC Linkers Isoform-spezifische Produkte anzeigen
MoreAlle PROTAC Linkers Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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Cleavable Linker |
Alkyl/ether |
PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2144395-59-3
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Appearance Oil
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Molecular Weight 693.74
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Formel C36H43N3O11
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Color Light yellow to yellow
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SMILES
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCNC(CCC(N2C3=CC=CC=C3C#CC4=CC=CC=C4C2)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (144.15 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4415 mL | 7.2073 mL | 14.4146 mL | 36.0366 mL |
| 5 mM | 0.2883 mL | 1.4415 mL | 2.8829 mL | 7.2073 mL | |
| 10 mM | 0.1441 mL | 0.7207 mL | 1.4415 mL | 3.6037 mL | |
| 15 mM | 0.0961 mL | 0.4805 mL | 0.9610 mL | 2.4024 mL | |
| 20 mM | 0.0721 mL | 0.3604 mL | 0.7207 mL | 1.8018 mL | |
| 25 mM | 0.0577 mL | 0.2883 mL | 0.5766 mL | 1.4415 mL | |
| 30 mM | 0.0480 mL | 0.2402 mL | 0.4805 mL | 1.2012 mL | |
| 40 mM | 0.0360 mL | 0.1802 mL | 0.3604 mL | 0.9009 mL | |
| 50 mM | 0.0288 mL | 0.1441 mL | 0.2883 mL | 0.7207 mL | |
| 60 mM | 0.0240 mL | 0.1201 mL | 0.2402 mL | 0.6006 mL | |
| 80 mM | 0.0180 mL | 0.0901 mL | 0.1802 mL | 0.4505 mL | |
| 100 mM | 0.0144 mL | 0.0721 mL | 0.1441 mL | 0.3604 mL |
DBCO-PEG5-NHS ester Related Classifications
HY-126885 Related Classifications
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