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Art. -Nr.: HY-N17465

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Dendronobiloside D

Dendronobiloside D is a sesquiterpene glycoside that can be isolated from Dendrobium officinale. Dendronobiloside D is an immunosuppressant that promotes the differentiation of CD4⁺ T cells into Treg cells.

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CAS. Nr.: 526222-27-5
Formel: C₂₇H₄₄O₁₂
Molecular Weight:560.63

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Dendronobiloside D Chemical Structure

CAS. Nr.: 526222-27-5

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

IL-12

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In Vitro

Dendronobiloside D downregulated the expression of IFNG, IL-6, and IL-12 mRNA in primary T cells, and upregulated the expression of TGFB mRNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_0-t	AUC_0-∞	C_max	T_max	T_1/2	CL_z/F	V_z/F
Rat^[1]	6.25 g/kg	p.o.	14.38 ± 1.72 μg/L·h	17.29 ± 1.99 μM/L·h	2.28 ± 0.18 μg/L	1.50 ± 0.55 h	5.72 ± 2.91 h	6.11 ± 0.74 L/h/kg	26.36 ± 32.39 L/kg

In Vivo

Dendronobiloside D (6.25 g/kg; p.o.; single dose), administered as part of a Dendrobium nobile aqueous extract to rats, shows low plasma exposure with a C_max of 2.28 ± 0.18 μg/L, rapid absorption with a T_max of 1.50 h, and a terminal elimination half-life of 5.72 h^[2].
Dendronobiloside D (6.25 g/kg; i.g.; single dose), administered as part of a Dendrobium nobile aqueous extract to rats, distributes widely to visceral and gastrointestinal tissues (excluding the brain) with highest concentrations in the small intestine, stomach, and large intestine^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats (male, 6-8 weeks old, 220±20 g)^[1]
Dosage:

6.25 g/kg (equivalent raw herb dose, as component of Dendrobium nobile aqueous extract)
Administration:

i.g.; single dose
Result:

Was detectable in all collected tissues except the brain.
Reached distribution concentration peaks generally within 2 hours post-administration.
Showed declining distribution concentrations between 2 and 6 hours post-administration.
Had tissue distribution levels ranked as: small intestine > stomach > large intestine > pancreas > lungs > kidneys > liver > heart > thymus > spleen > brain (undetectable).
Exhibited concentrations in the gastrointestinal tract (small intestine, stomach, large intestine) approximately 30 times higher than in heart, thymus, and spleen.

Chemical Information

CAS. Nr. 526222-27-5
Molecular Weight 560.63
Formel C₂₇H₄₄O₁₂
SMILES

OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OCC2=C3[C@](C=C(CC3)C)([H])[C@@H](CC2)C(C)CO[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wu X, et al. Pharmacokinetics and tissue distribution of key sesquiterpene glycosides in Dendrobium nobile analyzed by UHPLC-Q-Trap-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2025;1250:124386. [Content Brief]

[2]. Wu X, et al. Capture and Validation of T Cell Modulatory Bioactive Constituents from Dendrobium nobile Using Biolayer Interferometry Coupled with UHPLC-Q-TOF MS/MS[J].

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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Dendronobiloside D

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Biologische Aktivität

Chemical Information

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Verweise

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Dendronobiloside D Related Classifications

HY-N17465 Related Classifications