country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-159768A

Copy Link Print Information

DOTAGA.Glu.(FAPi)2

DOTAGA.Glu.(FAPi) 2 is a FAPI homodimer in which a central glutamic acid (Glu) linker connects FAPI and a chelator. Radiolabeled with gallium-⁶⁸, lutetium-¹⁷⁷ or terbium-¹⁶¹, DOTAGA.Glu.(FAPi) 2 is applicable to FAP-positive cancer PET imaging studies. DOTAGA.Glu.(FAPi) 2 is suitable for research related to prostate adenocarcinoma and recurrent glioblastoma multiforme.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2882922-68-9
Formel: C₆₆H₈₁F₄N₁₅O₁₇
Molecular Weight:1432.43

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

DOTAGA.Glu.(FAPi)2 Chemical Structure

CAS. Nr.: 2882922-68-9

Größe

Preis

Verfügbarkeit

Menge

Sample (0.1mg)

In-stock

(In Japan)

Apply Now

Angebot einholen Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability Angebot einholen Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability

Massenanfrage

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

One-stop CDMO Service

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

Alle Radionuclide-Drug Conjugates (RDCs) Isoform-spezifische Produkte anzeigen :

In Vitro

^68/natGa-DOTAGA.Glu.(FAPi)2 and ^177/natLu-DOTAGA.Glu.(FAPi)2 (0.1-10 nM) bind to FAP⁺ CAFs with high affinity, with K_d values of 0.8 nM and 0.7 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

[177Lu]LuDOTAGA.Glu.(FAPi)2 (600 pmol; intravenous injection) exhibits slightly longer initial and terminal half-lives than [¹⁷⁷Lu]Lu-DO3A.Glu.(FAPI)2 in healthy nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2882922-68-9
Molecular Weight 1432.43
Formel C₆₆H₈₁F₄N₁₅O₁₇
SMILES

O=C(N1[C@@H](CC(F)(C1)F)C#N)CNC(C2=CC=NC3=C2C=C(OCCCCNC([C@H](CCC(NCCCCOC4=CC5=C(N=CC=C5C(NCC(N6[C@@H](CC(F)(C6)F)C#N)=O)=O)C=C4)=O)NC(CCC(N7CCN(CCN(CCN(CC7)CC(O)=O)CC(O)=O)CC(O)=O)C(O)=O)=O)=O)C=C3)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bilinska A, et al. Preclinical evaluation of DOTAGA.Glu.(FAPI)₂ and DO3A.Glu.(FAPI)₂ as theranostics with human dosimetry extrapolation to lutetium-177 and terbium-161 analogs. Eur J Nucl Med Mol Imaging. 2026;53(3):1887-1901. [Content Brief]

[2]. Ballal S, et al. [¹⁷⁷Lu]Lu-DOTAGA.Glu.(FAPi)₂ Radionuclide Therapy: a New Treatment Option for Patients with Glioblastoma Multiforme. Nucl Med Mol Imaging. 2024;58(1):32-34. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Angebot einholen Auf Lager