DW18134
DW18134 is an inhibitor for interleukin receptor-associated kinase 4 (IRAK 4) with an IC50 of 11.2 nM. DW18134 inhibits phosphorylation of IRAK4 and IKK, downregulates the secretion of TNF-α and IL-6. DW18134 attenuates the Lipopolysaccharides (HY-D1056)-induced peritonitis and DSS-induced colitis in mouse models, and protects the intestinal barrier function .
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- CAS. Nr.: 2626988-87-0
- Formel: C24H21N5O3
- Molecular Weight:427.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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IRAK4 11.2 nM (IC50) |
Chemical Information
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CAS. Nr. 2626988-87-0
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Molecular Weight 427.46
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Formel C24H21N5O3
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SMILES
CC(O1)(C)CC2=C1C=C(C3=CC=NC=C3)C(NC(C4=COC(C5=CC(N)=NC=C5)=N4)=O)=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
DW18134 Related Classifications
HY-161620 Related Classifications
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