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Art. -Nr.: HY-183637

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E822-1968

E822-1968 is an UT-A2 inhibitor with a human IC₅₀ of 0.44 μM. E822-1968 blocks urea transport mediated by UT-A2. E822-1968 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.

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CAS. Nr.: 1037259-63-4
Formel: C₁₉H₁₉N₃O₃
Molecular Weight:337.37

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

E822-1968 Chemical Structure

CAS. Nr.: 1037259-63-4

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Bioz

Biologische Aktivität

Beschreibung

In Vitro

E822-1968 potently inhibits UT-A2-mediated urea transport in UT-A2-overexpressing HEK293F cells with an IC₅₀ of 0.44 μM^[1].
E822-1968 weakly inhibits UT-A3-mediated urea transport in UT-A3-overexpressing HEK293F cells with an IC₅₀ of 3.42 μM^[1].
E822-1968 (10 nM-100 μM; 50 seconds) does not inhibit UT-B-mediated urea transport in UT-B-overexpressing HEK293F cells^[1].
E822-1968 (1-10 μM; 30 minutes) does not inhibit rat UT-A1-mediated urea transport in stably expressing MDCK cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1037259-63-4
Molecular Weight 337.37
Formel C₁₉H₁₉N₃O₃
SMILES

COC1=CC(CNC(C2=CC(C3=CC=CC(OC)=C3)=NN2)=O)=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Liu L, et al. Hotspot pocket-based discovery of urea transporter selective inhibitors. Nat Commun. Published online April 20, 2026. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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