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Art. -Nr.: HY-185180

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Ferrioxamine B

Ferrioxamine B is a bacterial desferrioxamine siderophore produced by actinomycetes. Ferrioxamine B acts as a ligand for FpvB and FoxA, and is transported into Pseudomonas aeruginosa via the FpvB and FoxA transporters. Ferrioxamine B competitively binds to FpvB, thereby antagonizing the uptake of thiostrepton into Pseudomonas aeruginosa. Ferrioxamine B can provide an iron source to support the growth of Pseudomonas aeruginosa under iron-limiting conditions.

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CAS. Nr.: 14836-73-8
Formel: C₂₅H₄₅FeN₆O₈
Molecular Weight:613.51

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Ferrioxamine B Chemical Structure

CAS. Nr.: 14836-73-8

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Beschreibung

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In Vitro

Ferrioxamine B-Fe³⁺ (1 hour) binds FpvB in P. aeruginosa PA14 ΔfpvA ΔfpvB mutant with two distinct sites (K_d1 = 100 ng/mL, K_d2 = 270,000 ng/mL) and is taken up via a proton motive force-dependent mechanism^[1].
Ferrioxamine B (0.0-10 μg/mL) competes with thiostrepton (0.0-17 μg/mL) for binding to FpvB in P. aeruginosa PA14 ΔfpvA ΔfpvB mutant, reducing Thiostrepton (HY-B0990) susceptibility^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 14836-73-8
Molecular Weight 613.51
Formel C₂₅H₄₅FeN₆O₈
SMILES

NCCCCCN1[O-][Fe+3]23([O]=C1CCC4=O)([O-]N(CCCCCN5)C(C)=[O]3)[O-]N(CCCCCN4)C(CCC5=O)=[O]2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chan DCK, et al. Pseudomonas aeruginosa FpvB Is a High-Affinity Transporter for Xenosiderophores Ferrichrome and Ferrioxamine B. mBio. 2023;14(1):e0314922. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Ferrioxamine B

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Ferrioxamine B Related Classifications

HY-185180 Related Classifications