DHX15 - DEAH-box helicase 15 Gene

Also Known as DBP1; DDX15; PRP43; PRPF43; hPrp43; PrPp43p

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1665

About DHX15

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:24,527,475-24,584,554 (from NCBI)

This gene has 10 transcripts (splice variants), 271 orthologues and 18 paralogues. Ubiquitous expression in bone marrow (RPKM 42.0), lymph node (RPKM 36.6) and 25 other tissues.

Summary

The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

DHX15 Products (1)

mRNA Protein Name
NM_001358.3 NP_001349.2 ATP-dependent RNA helicase DHX15

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables RNA binding IDA
IDA: Inferred from direct assay
32179686 GOA
enables RNA helicase activity IDA
IDA: Inferred from direct assay
32179686 GOA
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
21266579 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17332742 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in antiviral innate immune response IDA
IDA: Inferred from direct assay
24990078 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
24990078 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
24990078 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of U12-type spliceosomal complex IDA
IDA: Inferred from direct assay
15146077 GOA
part of U2-type post-mRNA release spliceosomal complex IDA
IDA: Inferred from direct assay
19103666 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHX15 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (148 - 296)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (382 - 476)

HA2

HA2: Helicase associated domain (HA2) (539 - 628)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (662 - 765)

  • 0
  • 200
  • 400
  • 600
  • 795 a.a.
Protein Preferred Names Protein Names

ATP-dependent RNA helicase DHX15

  • ATP-dependent RNA helicase #46

DHX15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
DHX15 O43143 ZGPAT Homo sapiens Q8N5A5-2
Y2H Prey Pooling
25416956
Intra
DHX15 O43143 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
25416956
Intra
DHX15 O43143 ZGPAT Homo sapiens Q8N5A5-2
Y2H Prey Pooling
32296183
Intra
DHX15 O43143 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
32296183
Intra
DHX15 O43143 ZGPAT Homo sapiens Q8N5A5-2
Y2H Array
25416956
Intra
DHX15 O43143 ZGPAT Homo sapiens Q8N5A5-2
Y2H Array
32296183
Intra
DHX15 O43143 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
Intra
DHX15 O43143 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
Intra
DHX15 O43143 FXR1 Homo sapiens P51114-2
Validated Y2H
32296183
Intra
DHX15 O43143 CAMSAP3 Homo sapiens Q9P1Y5-2
Validated Y2H
32296183
Intra
DHX15 O43143 CAMSAP3 Homo sapiens Q9P1Y5-2
Y2H Prey Pooling
32296183
Intra
DHX15 O43143 CAMSAP3 Homo sapiens Q9P1Y5-2
Y2H Array
32296183
Intra
DHX15 O43143 NUDCD1 Homo sapiens Q96RS6-1
Anti Tag CoIP
29021621
Intra
DHX15 O43143 SF3A2 Homo sapiens Q15428
Anti Tag CoIP
24304693
Intra
DHX15 O43143 SUGP1 Homo sapiens Q8IWZ8
Y2H
22365833
Intra
DHX15 O43143 KRT75 Homo sapiens O95678
Validated Y2H
32296183
Intra
DHX15 O43143 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra
DHX15 O43143 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra
DHX15 O43143 ZGPAT Homo sapiens Q8N5A5
Y2H Prey Pooling
25416956
Intra
DHX15 O43143 ZGPAT Homo sapiens Q8N5A5
Y2H Array
25416956
Intra
DHX15 O43143 RBM5 Homo sapiens P52756
Y2H
22569250
Intra
DHX15 O43143 RBM5 Homo sapiens P52756
Anti Tag CoIP
22569250
Intra
DHX15 O43143 RBM5 Homo sapiens P52756
Y2H
22365833
Intra
DHX15 O43143 RBM5 Homo sapiens P52756
Anti Tag CoIP
22365833
Intra
DHX15 O43143 RBM5 Homo sapiens P52756
Anti Tag CoIP
24304693
Intra
DHX15 O43143 RBM10 Homo sapiens P98175
Anti Tag CoIP
29021621
Intra
DHX15 O43143 RBM17 Homo sapiens Q96I25
Y2H Array
32296183
Intra
DHX15 O43143 RBM17 Homo sapiens Q96I25
Anti Tag CoIP
22365833
Intra
DHX15 O43143 RBM17 Homo sapiens Q96I25
Anti Tag CoIP
29021621
Intra
DHX15 O43143 RBM17 Homo sapiens Q96I25
Y2H Prey Pooling
32296183
Intra
DHX15 O43143 RBM17 Homo sapiens Q96I25
Y2H
22365833
Intra
DHX15 O43143 RBM17 Homo sapiens Q96I25
Y2H Prey Pooling
25416956
Intra
DHX15 O43143 RBM17 Homo sapiens Q96I25
Validated Y2H
32296183
Intra
DHX15 O43143 AGGF1 Homo sapiens Q8N302
Y2H Array
32296183
Intra
DHX15 O43143 AGGF1 Homo sapiens Q8N302
Validated Y2H
32296183
Intra
DHX15 O43143 AGGF1 Homo sapiens Q8N302
Y2H Prey Pooling
32296183
Intra
DHX15 O43143 GPANK1 Homo sapiens O95872
Validated Y2H
32296183
Intra
DHX15 O43143 NKRF Homo sapiens O15226
Anti Tag CoIP
29021621
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

  • Mrx12

  • Mrx35

  • X-Linked Mental Retardation 12

  • X-Linked Mental Retardation 35
Posterior Cerebral Artery Infarction

  • Infarction, Posterior Cerebral Artery
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03748 DHX15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20393 Dhx15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26902 Dhx15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DHX15 RGD RGD:1308072
Mus musculus DHX15 MGD MGI:1099786
Felis catus DHX15 VGNC VGNC:61474
Canis familiaris DHX15 VGNC VGNC:39939
Bos taurus DHX15 VGNC VGNC:28048
Macaca mulatta DHX15 VGNC VGNC:71760
Others DHX15 NCBI