GNAI2 - G protein subunit alpha i2 Gene

Also Known as GIP; HG1C; GNAI2B; H_LUCA15.1; H_LUCA16.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2771

About GNAI2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,227,068-50,263,358 (from NCBI)

This gene has 12 transcripts (splice variants), 292 orthologues, 15 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 106.7), bone marrow (RPKM 93.2) and 25 other tissues.

Summary

The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of Adenylate Cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GNAI2 Products (6)

mRNA Protein Name
NM_001166425.2 NP_001159897.1 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 2
NM_001282617.2 NP_001269546.1 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 3
NM_001282618.2 NP_001269547.1 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 4
NM_001282619.2 NP_001269548.1 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 5
NM_001282620.2 NP_001269549.1 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 6
NM_002070.4 NP_002061.1 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cell division IMP
IMP: Inferred from mutant phenotype
17635935 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21079996 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in centrosome IDA
IDA: Inferred from direct assay
17635935 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17635935 GOA
located in midbody IDA
IDA: Inferred from direct assay
17635935 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17635935 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNAI2 Protein Structure

G-alpha

G-alpha: G-protein alpha subunit (7 - 344)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(i) subunit alpha-2

  • GTP-binding regulatory protein Gi alpha-2 chain

GNAI2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
GNAI2 P04899 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
GNAI2 P04899 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
GNAI2 P04899 RGS20 Homo sapiens O76081-6
Y2H Array
25416956
Intra
GNAI2 P04899 PCP2 Homo sapiens Q8IVA1
Validated Y2H
32296183
Intra
GNAI2 P04899 CXCR5 Homo sapiens P32302
CoIP
15251452
Intra
GNAI2 P04899 CXCR5 Homo sapiens P32302
Anti Bait CoIP
23773523
Intra
GNAI2 P04899 CXCR5 Homo sapiens P32302
Experimental Interac
15251452
Intra
GNAI2 P04899 GPSM3 Homo sapiens Q9Y4H4
Validated Y2H
25416956
Intra
GNAI2 P04899 GPSM3 Homo sapiens Q9Y4H4
Y2H Prey Pooling
25416956
Intra
GNAI2 P04899 GNB1 Homo sapiens P62873
Anti Tag CoIP
33961781
Intra
GNAI2 P04899 NCF1 Homo sapiens P14598
Anti Bait CoIP
16782902
Cross
GNAI2 P04899 Oprm1 Mus musculus P42866
Anti Bait CoIP
18599439
Cross
GNAI2 P04899 Oprm1 Mus musculus P42866
Anti Tag CoIP
18599439
Intra
GNAI2 P04899 MDFI Homo sapiens Q99750
Pull Down
16189514
Intra
GNAI2 P04899 MDFI Homo sapiens Q99750
Y2H Pooling
16189514
Intra
GNAI2 P04899 TRIP6 Homo sapiens Q15654
Validated Y2H
25416956
Intra
GNAI2 P04899 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

GNAI2 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P83199 GNAI2 Antibody (YA2944) WB, IHC-P Human, Mouse, Rat
HY-P83199A GNAI2 Antibody (YA2944)(PBS only) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Ventricular Tachycardia, Familial

  • Familial Ventricular Tachycardia

  • Ventricular Tachycardia, Familial Polymorphic

  • Ventricular Tachycardia, Idiopathic
Granulosa Cell Tumor Of The Ovary

  • Adult Granulosa Cell Tumor Of The Ovary

  • Gct Of The Ovary

  • Gtct

  • Granulosa Theca Cell Tumor

  • Granulosa Theca Cell Tumor Of The Ovary
Pituitary Adenoma 4, Acth-Secreting

  • PITA4

  • Cushing Disease, Pituitary

  • Pituitary Adenoma 4, Acth-Secreting, Somatic

  • Cushing Disease

  • Pituitary Cushing Disease

  • Adenoma, Pituitary, Acth-Secreting, Type 4

  • Pituitary-Dependent Cushing'S Disease
Conn'S Syndrome

  • Cushing Syndrome

  • Hyperaldosteronism

  • Primary Hyperaldosteronism

  • Hypercortisolism

  • Primary Aldosteronism

  • Cushing'S Syndrome

  • Adrenal Gland Hyperfunction

  • Conn Syndrome

  • Hyperadrenalism

  • Ectopic Acth Syndrome

  • Hyperadrenocorticism

  • Cushing Disease

  • Cushing'S Disease

  • Adrenal Cortex Adenoma

  • Corticotroph Pituitary Adenoma

  • Pituitary Corticotroph Micro-Adenoma

  • Pituitary-Dependent Cushing Syndrome

  • Pituitary Acth Hypersecretion

  • Acth Syndrome, Ectopic

  • Acth-Secreting Pituitary Adenoma

  • Adrenal Hyperfunction Resulting From Pituitary Acth Excess

  • Ectopic Adrenocorticotropic Hormone Syndrome

  • Nodular Primary Adrenocortical Dysplasia

  • Pituitary Dependent Cushing Syndrome

  • Pituitary Cushing Syndrome

  • Pituitary-Dependant Cushing Syndrome

  • Pituitary-Dependant Hypercortisolism

  • Pituitary-Dependant Hypercortisolism Disorder

  • Aldosteronism Primary

  • Acth Syndrome Ectopic

  • Adrenal Cushing'S Syndrome

  • Adrenal Cortical Adenoma

  • Cushing Syndrome Nos

  • Cortisol Hypersecretion

  • Corticoadrenal Hypersecretion

  • Cushing Syndrome Secondary To Ectopic Acth-Secretion

  • Ectopic Cushing Syndrome

  • Hypercortisolism Due To Nonpituitary Tumour

  • Ectopic Acth - [Adrenocorticotropic Hormone] Secretion

  • Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome

  • Idiopathic Aldosteronism

  • Aldosteronism

  • Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia

  • Primary Aldosteronism Due To Adrenal Hyperplasia
Hyperinsulinemic Hypoglycemia, Familial, 5

  • Hyperinsulinism Due To Insr Deficiency

  • HHF5

  • Familial Hyperinsulinemic Hypoglycemia 5

  • Hyperinsulinemic Hypoglycemia Due To Insr Deficiency

  • Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency

  • Congenital Hyperinsulinism

  • Persistent Hyperinsulinemic Hypoglycemia Of Infancy

  • Phhi

  • Hyperinsulinemic Hypoglycemia Familial 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS05535 GNAI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21585 Gnai2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28103 Gnai2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GNAI2 VGNC VGNC:62617
Rattus norvegicus GNAI2 RGD RGD:620243
Mus musculus GNAI2 MGD MGI:95772
Canis familiaris GNAI2 VGNC VGNC:41302
Bos taurus GNAI2 VGNC VGNC:29450
Macaca mulatta GNAI2 VGNC VGNC:73090
Others GNAI2 NCBI