IL23A - interleukin 23 subunit alpha Gene

Also Known as P19; SGRF; IL-23; IL-23A; IL23P19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51561

About IL23A

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,338,884-56,340,410 (from NCBI)

This gene has 3 transcripts (splice variants) and 96 orthologues. Biased expression in testis (RPKM 4.7), urinary bladder (RPKM 2.4) and 11 other tissues.

Summary

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

IL23A Products (1)

mRNA	Protein	Name
NM_016584.3	NP_057668.1	interleukin-23 subunit alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
contributes to interleukin-23 receptor binding	IDA IDA: Inferred from direct assay	11114383	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11114383	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	12023369	GOA
involved in cell surface receptor signaling pathway via STAT	IDA IDA: Inferred from direct assay	19088061	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	15114670	GOA
involved in negative regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	16751425	GOA
involved in positive regulation of NK T cell activation	IDA IDA: Inferred from direct assay	19088061	GOA
involved in positive regulation of NK T cell proliferation	IDA IDA: Inferred from direct assay	19088061	GOA
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	12023369	GOA
involved in positive regulation of T-helper 1 type immune response	IDA IDA: Inferred from direct assay	15114670	GOA
involved in positive regulation of activated T cell proliferation	IDA IDA: Inferred from direct assay	11114383	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	12421946	GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production	IDA IDA: Inferred from direct assay	20027291	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	15265908	GOA
involved in positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	20027291	GOA
involved in positive regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	16482511	GOA
involved in positive regulation of natural killer cell proliferation	IDA IDA: Inferred from direct assay	19088061	GOA
involved in positive regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	17888176	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16751425	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	11114383	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of interleukin-23 complex	IDA IDA: Inferred from direct assay	11114383	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL23A Protein Structure

IL6

0
100
189 a.a.

Protein Preferred Names	Protein Names
interleukin-23 subunit alpha	IL-23 subunit alpha IL-23-A IL-23p19 JKA3 induced upon T-cell activation interleukin 23 p19 subunit interleukin 23, alpha subunit p19 interleukin-23 subunit p19 interleukin-six, G-CSF related factor

IL23A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	IL23A	Q9NPF7	IL23R	Homo sapiens	Q5VWK5	Anti Tag CoIP	12023369
Intra	IL23A	Q9NPF7	IL12B	Homo sapiens	P29460	X-Ray Diffraction	18680750
Intra	IL23A	Q9NPF7	IL12B	Homo sapiens	P29460	Anti Tag CoIP	12023369
Intra	IL23A	Q9NPF7	IL12B	Homo sapiens	P29460	Anti Tag CoIP	11114383
Intra	IL23A	Q9NPF7	PEX19	Homo sapiens	P40855	Validated Y2H	25416956
Intra	IL23A	Q9NPF7	PEX19	Homo sapiens	P40855	Y2H Prey Pooling	32296183
Intra	IL23A	Q9NPF7	PEX19	Homo sapiens	P40855	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL23A Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P70736	IL-23 Protein, Human (HEK293, C-His)	Q9NPF7 (R20-P189)&P29460 (I23-S328)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73193	IL-23 Protein, Human (HEK293, His)	Q9NPF7/NP_057668.1 (R20-P189)&P29460/NP_002178.2 (I23-S328)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P74816	IL-23 Protein, Human (Biotinylated, HEK293, His)	Q9NPF7 (R20-P189)&P29460 (I23-S328)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P74874	Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His)	Q9NPF7 (R20-P189)&P43432 (M23-S335)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76432	IL-23 alpha Protein, Human (HEK293, Fc)	Q9NPF7 (R20-P189)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P77712	Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His-Avi)	Q9NPF7 (R20-P189)&P43432 (M23-S335)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700114AF	Animal-Free IL-23 alpha Protein, Human (His)	Q9NPF7 (R20-P189)	≥ 95%, as determined by reducing SDS-PAGE.

IL23A Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81718	IL-23 alpha Antibody (YA1463)	WB	Human

Related Diseases

Diseases	Alias
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Disease Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Candidiasis	Systemic Candidiasis Invasive Candidiasis Disseminated Candidiasis Systemic Candida Infections Candidiasis, Invasive
Psoriasis
Hidradenitis	Hydradenitis
Epiglottitis	Acute Epiglottitis Acute Epiglottitis And Supraglottitis Acute Epiglottiditis Epiglottiditis Epiglottitis Nos
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Autoimmune Disease Of Skin And Connective Tissue
Autoimmune Cholangitis	Autoimmune Cholangiopathy
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Enteritis, Granulomatous Crohn'S Disease Of Colon Granulomatous Colitis Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Enteritis Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Colitis
Erythema Nodosum
Hidradenitis Suppurativa	Acne Inversa Suppurative Hidradenitis Acne Inversa, Familial Apocrinitis Hidradenitides, Suppurative Hidradenitis, Suppurative Suppurative Hidradenitides Inverse Acne
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Spondyloarthropathy	Spondylarthropathies Spondarthropathy Spondylarthrosis Spondyloarthropathy, Susceptibility To Spondylarthritis
Demyelinating Disease	Demyelinating Diseases Demyelinating Disorder
Nail Disease	Nail Diseases Abnormality Of The Nail Nail Anomaly
Spondylitis
Gastroenteritis	Cholera Morbus Infectious Colitis, Enteritis And Gastroenteritis Enteritis Due To Astrovirus Rotaviral Gastroenteritis Viral Gastroenteritis Due To Rotavirus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P990057	Picankibart	Inhibitor	98.00%	Phase 3

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-176535	KB-0118	Inhibitor	/	Unkown
HY-RS06739	IL23A Human Pre-designed siRNA Set A		/	Unkown
HY-RS06740	Il23a Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS06741	Il23a Rat Pre-designed siRNA Set A		/	Unkown
HY-174616	Human IL23R mRNA		/	Unkown
HY-174617	Human IL23A mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL23A	MGD	MGI:1932410
Bos taurus	IL23A	VGNC	VGNC:30146
Canis familiaris	IL23A	VGNC	VGNC:41972
Felis catus	IL23A	VGNC	VGNC:62907
Macaca mulatta	IL23A	VGNC	VGNC:73601
Rattus norvegicus	IL23A	RGD	RGD:620873
Others	IL23A	NCBI