BAK1 - BCL2 antagonist/killer 1 Gene

Also Known as BAK; CDN1; BCL2L7; BAK-LIKE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 578

About BAK1

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:33,572,552-33,580,276 (from NCBI)

This gene has 2 transcripts (splice variants), 129 orthologues and 8 paralogues. Ubiquitous expression in duodenum (RPKM 20.6), small intestine (RPKM 16.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce Apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

BAK1 Products (5)

mRNA	Protein	Name
NM_001188.4	NP_001179.1	bcl-2 homologous antagonist/killer
XM_047419196.1	XP_047275152.1	bcl-2 homologous antagonist/killer isoform X3
XM_047419194.1	XP_047275150.1	bcl-2 homologous antagonist/killer isoform X2
XM_011514780.2	XP_011513082.1	bcl-2 homologous antagonist/killer isoform X3
XM_011514779.4	XP_011513081.1	bcl-2 homologous antagonist/killer isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	10950869	GOA
enables porin activity	IDA IDA: Inferred from direct assay	22006182	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9027312	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	10837489	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	23028632	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	25296756	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in activation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	18387192	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	23028632	GOA
involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15901672	GOA
involved in cellular response to UV	IMP IMP: Inferred from mutant phenotype	15901672	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in establishment or maintenance of transmembrane electrochemical gradient	IDA IDA: Inferred from direct assay	9843949	GOA
involved in intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	22006182	GOA
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15901672	GOA
involved in negative regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	15901672	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	9111042	GOA
involved in positive regulation of proteolysis	IDA IDA: Inferred from direct assay	18387192	GOA
involved in regulation of mitochondrial membrane permeability	IDA IDA: Inferred from direct assay	9843949	GOA
involved in regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	9843949	GOA
involved in release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	9843949	GOA
involved in release of cytochrome c from mitochondria	IGI IGI: Inferred from genetic interaction	21041309	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of BAK complex	IDA IDA: Inferred from direct assay	10950869	GOA
part of BAK complex	IPI IPI: Inferred from physical interaction	32929280	GOA
part of Bcl-2 family protein complex	IDA IDA: Inferred from direct assay	21041309	GOA
part of Bcl-2 family protein complex	IPI IPI: Inferred from physical interaction	22515821	GOA
is active in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	22006182	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	29531808	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	9843949	GOA
part of pore complex	IDA IDA: Inferred from direct assay	9843949	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAK1 Protein Structure

Bcl-2

0
100
200
211 a.a.

Protein Preferred Names	Protein Names
bcl-2 homologous antagonist/killer	BCL2-like 7 protein apoptosis regulator BAK bcl-2-like protein 7 bcl2-L-7 pro-apoptotic protein BAK

BAK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	BAK1	Q16611	MCL1	Homo sapiens	Q07820	Anti Bait CoIP	17097560
Intra	BAK1	Q16611	MCL1	Homo sapiens	Q07820	Anti Tag CoIP	19968986
Intra	BAK1	Q16611	MCL1	Homo sapiens	Q07820	Anti Bait CoIP	23680104
Intra	BAK1	Q16611	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	BAK1	Q16611	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	BAK1	Q16611	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817-1	FPS	17446862
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817-1	Anti Bait CoIP	15901672
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817-1	HTRF	14596824
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817-1	SPA	14596824
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817-1	Anti Bait CoIP	23680104
Intra	BAK1	Q16611	BAX	Homo sapiens	Q07812	Anti Tag CoIP	33961781
Intra	BAK1	Q16611	BAX	Homo sapiens	Q07812	CoIP	16439990
Intra	BAK1	Q16611	BID	Homo sapiens	P55957	Photoaffinity Labelling	12624108
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817	Y2H Array	31515488
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817	SLC	31467278
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817	Lumier	32814053
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817	Complementation	31467278
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817	Lumier	29997244
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817	Lumier	37398436
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817	BRET	29997244
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817	Y2H Pooling	16189514
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817	Y2H Array	31467278
Intra	BAK1	Q16611	BCL2L1	Homo sapiens	Q07817	BRET	37398436
Cross	BAK1	Q16611	Mcl1	Mus musculus	P97287	SPR	15901672
Intra	BAK1	Q16611	BCL2L2	Homo sapiens	Q92843	Validated Y2H	25416956
Intra	BAK1	Q16611	BCL2L2	Homo sapiens	Q92843	Validated Y2H	32296183
Intra	BAK1	Q16611	BCL2L2	Homo sapiens	Q92843	Y2H Array	25416956
Intra	BAK1	Q16611	BCL2	Homo sapiens	P10415	FPS	26004684
Intra	BAK1	Q16611	BCL2	Homo sapiens	P10415	Anti Bait CoIP	9463381
Cross	BAK1	Q16611	OPG045	vaccinia virus	P24356	CoIP	16439990
Cross	BAK1	Q16611	OPG045	vaccinia virus	P24356	Pull Down	16439990
Cross	BAK1	Q16611	OPG045	vaccinia virus	P24356	Peptide Array	16439990
Cross	BAK1	Q16611	OPG045	vaccinia virus	P24356	Competition Binding	16439990
Cross	BAK1	Q16611	Mfn2	Mus musculus	Q80U63	FRET	17606912
Cross	BAK1	Q16611	Mfn2	Mus musculus	Q80U63	Anti Tag CoIP	17606912

Cross: Cross-species interaction Intra: Intraspecies interaction

BAK1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80026	Bak Antibody (YA592)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
HY-P80563	Bak Antibody	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse
HY-P84615	Bak Antibody (YA4312)	IHC-P, FC, ELISA	Human
HY-P84615A	Bak Antibody (YA4312)(PBS only)	IHC-P, FC, ELISA	Human
HY-P86353	Bak Antibody (YA6045)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Keratoacanthoma	Ka - [Keratoacanthoma] Well-Differentiated Squamous Cell Carcinoma
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Childhood Germ Cell Cancer	Pediatric Germ Cell Tumor Paediatric Germ Cell Cancer Paediatric Germ Cell Neoplasm Pediatric Germ Cell Cancer Pediatric Germ Cell Neoplasm
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Absolute Glaucoma	Blind Hypertensive Eye Glaucoma Absolute
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Breast Disease	Breast Diseases
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-162858	BRD-810		98.00%	Unkown
HY-129461	Dibenzyl trisulfide	Inducer	98.24%	Unkown
HY-183601	Mcl-1-IN-22		/	Unkown
HY-E70788	BARK1 Recombinant Human Active Protein Kinase		/	Unkown
HY-RS01357	BAK1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01358	Bak1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01359	Bak1 Rat Pre-designed siRNA Set A		/	Unkown
HY-136999	7-O-Methyleucomol		/	Unkown
HY-174777	Human BAK1 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BAK1	VGNC	VGNC:70224
Rattus norvegicus	BAK1	RGD	RGD:621635
Mus musculus	BAK1	MGD	MGI:1097161
Felis catus	BAK1	VGNC	VGNC:102386
Bos taurus	BAK1	VGNC	VGNC:26416
Canis familiaris	BAK1	VGNC	VGNC:38375
Others	BAK1	NCBI