Nek7 - NIMA (never in mitosis gene a)-related expressed kinase 7 Gene

Also Known as 2810460C19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59125

Summary

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in positive regulation of DNA metabolic process and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human NEK7 (NIMA related kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

Nek7 Products (2)

mRNA Protein Name
NM_001311148.2 NP_001298077.1 serine/threonine-protein kinase Nek7 isoform 2
NM_021605.5 NP_067618.1 serine/threonine-protein kinase Nek7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables molecular function activator activity IDA
IDA: Inferred from direct assay
26553871 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26188091 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to potassium ion IDA
IDA: Inferred from direct assay
26814970 MGI
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
26642356 MGI
involved in positive regulation of NLRP3 inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
26814970 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26188091 MGI
located in nucleus IDA
IDA: Inferred from direct assay
26188091 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek7

  • NIMA-related expressed kinase 7

  • NIMA-related kinase 7

  • never in mitosis A-related kinase 7

  • nimA-related protein kinase 7

Nek7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Nek7 Q9ES74 Nlrp3 Mus musculus Q8R4B8
Anti Bait CoIP
26814970
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-172162 LC-04-045 Degrader 99.56% Unkown
HY-159520 Ofirnoflastum Inhibitor 99.93% Unkown
HY-173154B NK7-902 diTFA Degrader 99.88% Unkown
HY-175452 MRT-3486 Degrader 99.62% Unkown
HY-163358 SLC3037 Inhibitor 99.85% Unkown
HY-176860 NEK7 degrader-1 Degrader 99.94% Unkown
HY-W998347 ABS-752 hydrochloride 98.81% Unkown
HY-174270 NLRP3-IN-79 Inhibitor 99.10% Unkown
HY-168737 NEK7-IN-2 Inhibitor / Unkown
HY-185311 NEK7 degrader-3 Degrader / Unkown
HY-180890 PPARγ agonist-21 Inhibitor / Unkown
HY-177559 NEK7 degrader-2 Degrader / Unkown
HY-177433 NEK7 degrader-4 Degrader / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nek7 NCBI NCBI:140609