KIF18A - kinesin family member 18A Gene

Also Known as PPP1R99; MS-KIF18A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81930

About KIF18A

Cytogenetic location: 11p14.1 Genomic coordinates (GRCh38): 11:28,020,619-28,108,156 (from NCBI)

This gene has 4 transcripts (splice variants), 190 orthologues and 41 paralogues. Biased expression in testis (RPKM 7.1), bone marrow (RPKM 2.7) and 11 other tissues.

Summary

KIF18A is a member of the Kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]

KIF18A Products (1)

mRNA Protein Name
NM_031217.4 NP_112494.3 kinesin-like protein KIF18A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables actin binding IPI
IPI: Inferred from physical interaction
18680169 GOA
enables microtubule binding IDA
IDA: Inferred from direct assay
18680169 GOA
enables microtubule plus-end binding IDA
IDA: Inferred from direct assay
17346968 GOA
enables plus-end-directed microtubule motor activity IDA
IDA: Inferred from direct assay
17346968 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15231748 GOA
enables tubulin-dependent ATPase activity IDA
IDA: Inferred from direct assay
17346968 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in microtubule depolymerization IDA
IDA: Inferred from direct assay
17346968 GOA
involved in mitotic metaphase chromosome alignment IDA
IDA: Inferred from direct assay
17346968 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in caveola IDA
IDA: Inferred from direct assay
17006958 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17006958 GOA
located in kinetochore microtubule IDA
IDA: Inferred from direct assay
17346968 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17006958 GOA
located in ruffle IDA
IDA: Inferred from direct assay
17006958 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF18A Protein Structure

Kinesin

Kinesin: Kinesin motor domain (17 - 355)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 898 a.a.
Protein Preferred Names Protein Names

kinesin-like protein KIF18A

  • protein phosphatase 1, regulatory subunit 99

KIF18A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
KIF18A Q8NI77 ANAPC4 Homo sapiens Q9UJX5
Anti Bait CoIP
23288039
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Asbestosis

  • Idiopathic Interstitial Pneumonitis - From Asbestos Exposure

  • Pulmonary Fibrosis - From Asbestos Exposure
Goldberg-Shprintzen Syndrome

  • Goldberg-Shprintzen Megacolon Syndrome

  • GOSHS

  • Megacolon-Microcephaly Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-132840 Sovilnesib Inhibitor 99.90% Phase 1

Pre-clinical Phase

Bioactive Molecules (25)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-153065 KIF18A-IN-6 Inhibitor 98.48% Unkown
HY-153066 VLS-1272 99.63% Unkown
HY-101770 BTB-1 Inhibitor 99.91% Unkown
HY-145034 KIF18A-IN-1 Inhibitor 98.06% Unkown
HY-162110 AM-9022 Inhibitor 99.53% Unkown
HY-144894 AM-5308 Inhibitor 99.15% Unkown
HY-162937 KIF18A-IN-13 Inhibitor 99.93% Unkown
HY-145802 KIF18A-IN-2 Inhibitor 98.49% Unkown
HY-145803 KIF18A-IN-3 Inhibitor 99.30% Unkown
HY-162531 KIF18A-IN-9 Inhibitor 95.03% Unkown
HY-RS07267 KIF18A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145827 KIF18A-IN-4 Inhibitor / Unkown
HY-158683 KIF18A-IN-11 Inhibitor / Unkown
HY-158757 KIF18A-IN-12 Inhibitor / Unkown
HY-162110A (S)-AM-9022 Control 99.88% Unkown
HY-162532 KIF18A-IN-10 Inhibitor / Unkown
HY-162667 EX05 Inhibitor / Unkown
HY-164978 KIF18A-IN-14 Inhibitor / Unkown
HY-164979 KIF18A-IN-15 Inhibitor / Unkown
HY-164980 KIF18A-IN-16 Inhibitor / Unkown
HY-178511 KIF18A-IN-17 Inhibitor / Unkown
HY-180170 KIF18A-IN-18 Inhibitor / Unkown
HY-180641 KIF18A-IN-19 Inhibitor / Unkown
HY-RS16612 Kif18a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23047 Kif18a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KIF18A RGD RGD:1561740
Felis catus KIF18A VGNC VGNC:63107
Macaca mulatta KIF18A VGNC VGNC:73944
Bos taurus KIF18A VGNC VGNC:30587
Canis familiaris KIF18A VGNC VGNC:42387
Mus musculus KIF18A MGD MGI:2446977
Others KIF18A NCBI