TRIM24 - tripartite motif containing 24 Gene

Also Known as PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8805

About TRIM24

Cytogenetic location: 7q33-q34 Genomic coordinates (GRCh38): 7:138,460,259-138,589,996 (from NCBI)

This gene has 6 transcripts (splice variants), 138 orthologues, 80 paralogues and is associated with 75 phenotypes. Ubiquitous expression in testis (RPKM 19.9), ovary (RPKM 16.3) and 25 other tissues.

Summary

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

TRIM24 Products (2)

mRNA Protein Name
NM_003852.4 NP_003843.3 transcription intermediary factor 1-alpha isoform b
NM_015905.3 NP_056989.2 transcription intermediary factor 1-alpha isoform a

TRIM24 Protein Structure

zf-B_box

zf-B_box: B-box zinc finger (159 - 203)

zf-B_box

zf-B_box: B-box zinc finger (220 - 257)

PHD

PHD: PHD-finger (828 - 871)

Bromodomain

Bromodomain: Bromodomain (908 - 988)

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  • 1050 a.a.
Protein Preferred Names Protein Names

transcription intermediary factor 1-alpha

  • E3 ubiquitin-protein ligase TRIM24

TRIM24 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TRIM24 O15164 TRIM33 Homo sapiens Q9UPN9
TAP
21531907
Intra
TRIM24 O15164 TRIM33 Homo sapiens Q9UPN9
Anti Tag CoIP
35271311
Intra
TRIM24 O15164 TRIM33 Homo sapiens Q9UPN9
TAP
24981860
Intra
TRIM24 O15164 TP53 Homo sapiens P04637
Anti Bait CoIP
19556538
Intra
TRIM24 O15164 TP53 Homo sapiens P04637
Anti Tag CoIP
19556538
Intra
TRIM24 O15164 ESR1 Homo sapiens P03372
Pull Down
21164480
Intra
TRIM24 O15164 ESR1 Homo sapiens P03372
Anti Bait CoIP
21164480
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TRIM24 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P700503 TRIM24 Protein, Human (P. pastoris, His) O15164 (K891-K1012) ≥ 90%, as determined by reducing SDS-PAGE.

TRIM24 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P810799 TRIM24 Antibody (YA10042) WB, IHC-P, ICC/IF Human
HY-P810950 TIF1 alpha Antibody WB, IHC-P Human, Mouse
HY-P82528 TRIM24 Antibody (YA2273) WB Human

Related Diseases

Diseases Alias
Differentiated Thyroid Carcinoma

  • Papillary Or Follicular Thyroid Carcinoma

  • Well-Differentiated Thyroid Carcinoma

  • Differentiated Thyroid Gland Carcinoma
Aortic Malignant Tumor

  • Aortic Malignant Neoplasm

  • Malignant Aortic Neoplasm
Adult Dermatomyositis

  • Adult Onset Dermatomyositis

  • Adult Type Dermatomyositis
Childhood Type Dermatomyositis

  • Juvenile Dermatomyositis

  • Juvenile Dm

  • Childhood Dermatomyositis

  • Amyopathic Dermatomyositis

  • Adm

  • Dermatomyositis Sine Myositis

  • Dermatomyositis, Childhood Type
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Laryngeal Small Cell Carcinoma

  • Small Cell Carcinoma Of Larynx
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-111519 dTRIM24 Inhibitor 99.89% Unkown
HY-102000B IACS-9571 hydrochloride Inhibitor 98.27% Unkown
HY-12518 OF-1 Inhibitor 98.93% Unkown
HY-143332 TRIM24/BRPF1-IN-2 Inhibitor 98.74% Unkown
HY-RS15029 TRIM24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-102000 IACS-9571 Inhibitor / Unkown
HY-102000A IACS-9571 TFA Inhibitor / Unkown
HY-161393 RB-CO-PEG5-C2-CO-VH032 / Unkown
HY-122626 BRPF1B/TRIM24-IN-1 Inhibitor / Unkown
HY-RS17565 Trim24 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24025 Trim24 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRIM24 VGNC VGNC:36321
Rattus norvegicus TRIM24 RGD RGD:1560596
Macaca mulatta TRIM24 VGNC VGNC:78562
Mus musculus TRIM24 MGD MGI:109275
Felis catus TRIM24 VGNC VGNC:80746
Canis familiaris TRIM24 VGNC VGNC:51835
Others TRIM24 NCBI