MTA1 - metastasis associated 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9112

About MTA1

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,419,827-105,470,729 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 14.9), spleen (RPKM 9.4) and 25 other tissues.

Summary

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

MTA1 Products (4)

mRNA	Protein	Name
NM_001203258.2	NP_001190187.1	metastasis-associated protein MTA1 isoform MTA1s
NM_001411061.1	NP_001397990.1	metastasis-associated protein MTA1 isoform 3
NM_001411062.1	NP_001397991.1	metastasis-associated protein MTA1 isoform 4
NM_004689.4	NP_004680.2	metastasis-associated protein MTA1 isoform MTA1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21965678	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	22926524	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16511565	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	21965678	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	21965678	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	9790534	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	19805145	GOA
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	24413532	GOA
involved in positive regulation of protein autoubiquitination	IDA IDA: Inferred from direct assay	19805145	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19805145	GOA
involved in response to ionizing radiation	IDA IDA: Inferred from direct assay	19805145	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of NuRD complex	IDA IDA: Inferred from direct assay	22926524	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24970816	GOA
located in microtubule	IDA IDA: Inferred from direct assay	24970816	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	24970816	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21965678	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTA1 Protein Structure

BAH

ELM2

GATA

0
200
400
600
715 a.a.

Protein Preferred Names	Protein Names
metastasis-associated protein MTA1	metastasis associated gene 1 protein

MTA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MTA1	Q13330	KRT40	Homo sapiens	Q6A162	Y2H Array	31515488
Intra	MTA1	Q13330	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	MTA1	Q13330	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	MTA1	Q13330	SH3GL1	Homo sapiens	Q6FGM0	Y2H Prey Pooling	25416956
Intra	MTA1	Q13330	SH3GL1	Homo sapiens	Q6FGM0	Y2H Array	25416956
Intra	MTA1	Q13330	MAGEA11	Homo sapiens	P43364-2	Validated Y2H	25416956
Intra	MTA1	Q13330	MAGEA11	Homo sapiens	P43364-2	Y2H Array	25416956
Intra	MTA1	Q13330	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	MTA1	Q13330	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	MTA1	Q13330	HDAC2	Homo sapiens	Q92769	Anti Tag CoIP	18451879
Intra	MTA1	Q13330	HDAC2	Homo sapiens	Q92769	Anti Tag CoIP	26028330
Intra	MTA1	Q13330	HDAC1	Homo sapiens	Q13547	Lumier	29997244
Intra	MTA1	Q13330	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	26028330
Intra	MTA1	Q13330	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	16511565
Intra	MTA1	Q13330	HDAC1	Homo sapiens	Q13547	CH-IP	26028330
Intra	MTA1	Q13330	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	18451879
Intra	MTA1	Q13330	KPNA3	Homo sapiens	O00505	Validated Y2H	25416956
Intra	MTA1	Q13330	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	25416956
Intra	MTA1	Q13330	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	MTA1	Q13330	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	MTA1	Q13330	KPNA4	Homo sapiens	O00629	Y2H Array	32296183
Intra	MTA1	Q13330	KPNA4	Homo sapiens	O00629	Y2H Prey Pooling	32296183
Intra	MTA1	Q13330	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	16511565
Intra	MTA1	Q13330	HIF1A	Homo sapiens	Q16665	Imaging	16511565
Intra	MTA1	Q13330	HIF1A	Homo sapiens	Q16665	Anti Bait CoIP	16511565
Intra	MTA1	Q13330	RBBP4	Homo sapiens	Q09028	Y2H Prey Pooling	25416956
Intra	MTA1	Q13330	RBBP4	Homo sapiens	Q09028	Anti Tag CoIP	33961781
Intra	MTA1	Q13330	SH3GL1	Homo sapiens	Q99961	Validated Y2H	32296183
Intra	MTA1	Q13330	SH3GL1	Homo sapiens	Q99961	Y2H Array	32296183
Intra	MTA1	Q13330	SH3GL1	Homo sapiens	Q99961	Y2H Prey Pooling	32296183
Intra	MTA1	Q13330	ZEB2	Homo sapiens	O60315	Anti Tag CoIP	26028330
Intra	MTA1	Q13330	ZEB2	Homo sapiens	O60315	Pull Down	26028330
Intra	MTA1	Q13330	ZEB2	Homo sapiens	O60315	CH-IP	26028330
Intra	MTA1	Q13330	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	MTA1	Q13330	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	25416956
Intra	MTA1	Q13330	EHMT2	Homo sapiens	Q96KQ7	Anti Bait CoIP	26028330
Intra	MTA1	Q13330	EHMT2	Homo sapiens	Q96KQ7	Pull Down	26028330
Intra	MTA1	Q13330	EHMT2	Homo sapiens	Q96KQ7	Anti Tag CoIP	26028330
Intra	MTA1	Q13330	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
Intra	MTA1	Q13330	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	MTA1	Q13330	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	MTA1	Q13330	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	MTA1	Q13330	JUN	Homo sapiens	P05412	Pull Down	21555589
Intra	MTA1	Q13330	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	MTA1	Q13330	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	MTA1	Q13330	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	MTA1	Q13330	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	MTA1	Q13330	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	MTA1	Q13330	PLEKHG4	Homo sapiens	Q58EX7	Validated Y2H	32296183
Intra	MTA1	Q13330	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
Intra	MTA1	Q13330	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

MTA1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P84536	MTA1 Antibody (YA4233)	WB, FC, ELISA	Human
HY-P84536A	MTA1 Antibody (YA4233)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Microphthalmia, Isolated 1	Isolated Microphthalmia 1 MCOP1 Mcop Anophthalmia, Clinical, Isolated Microphthalmos, Autosomal Recessive
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Developmental And Epileptic Encephalopathy 44	DEE44 Epileptic Encephalopathy, Early Infantile, 44 Eiee44 Developmental And Epileptic Encephalopathy, 44 Early Infantile Epileptic Encephalopathy 44 Encephalopathy, Epileptic, Early Infantile, Type 44
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS08746	MTA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19921	Mta1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26423	Mta1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MTA1	VGNC	VGNC:68334
Rattus norvegicus	MTA1	RGD	RGD:621018
Macaca mulatta	MTA1	VGNC	VGNC:74942
Mus musculus	MTA1	MGD	MGI:2150037
Canis familiaris	MTA1	VGNC	VGNC:43456
Others	MTA1	NCBI