HDAC6-IN-45
HDAC6-IN-45 (Compound 15) is a selective inhibitor for HDAC6 with IC50 of 15.2 nM. HDAC6-IN-45 exhibits neurotrophic through the upregulation of GAP43 and Beta-3 tubulin markers. HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, inhibits apoptosis in PC12, and exhibits neuroprotective efficacy in SCOP-induced zebrafish Alzheimer's Disease models. HDAC6-IN-45 exhibits antioxidant activity and good blood-brain barrier (BBB) permeability.
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- CAS. Nr.: 3048532-05-1
- Formel: C23H24FN3O2
- Molecular Weight:393.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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HDAC6 15.2 nM (IC50) |
HDAC3 13.6 μM (IC50) |
HDAC2 19.3 μM (IC50) |
HDAC1 28.2 μM (IC50) |
Chemical Information
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CAS. Nr. 3048532-05-1
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Molecular Weight 393.45
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Formel C23H24FN3O2
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SMILES
O=C(NO)C(C=C1)=CC=C1CN(CC2)CC3=C2C4=CC(F)=CC=C4N3CC5CC5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC6-IN-45 Related Classifications
HY-161783 Related Classifications
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