Art. -Nr.: HY-100749

HeE1-2Tyr

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC₅₀ of 27.6 μM) activity in vitro.

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Reinheit: 96.68%
CAS. Nr.: 2245195-67-7
Formel: C₃₃H₃₀N₂O₆S
Molecular Weight:582.67

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

HeE1-2Tyr Chemical Structure

CAS. Nr.: 2245195-67-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

RNA Polymerase

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	>100 μM Compound: 1; PBTZ	Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo Luminescent assay Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter Glo Luminescent assay	[PMID: 32435384]
Huh-7	EC₅₀	0.4 μM Compound: 1; PBTZ	Antiviral activity against Zika virus H/PF/2013 infected in human HuH7 cells assessed as reduction in virus replication incubated for 24 hrs by plaque reduction assay Antiviral activity against Zika virus H/PF/2013 infected in human HuH7 cells assessed as reduction in virus replication incubated for 24 hrs by plaque reduction assay	[PMID: 32435384]
Huh-7	EC₅₀	1.7 μM Compound: 1; PBTZ	Antiviral activity against Dengue virus 4 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay Antiviral activity against Dengue virus 4 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay	[PMID: 32435384]
Huh-7	EC₅₀	2.1 μM Compound: 1; PBTZ	Antiviral activity against Dengue virus 2 EDEN 3295 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay Antiviral activity against Dengue virus 2 EDEN 3295 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay	[PMID: 32435384]
Huh-7	EC₅₀	2.8 μM Compound: 1; PBTZ	Antiviral activity against Dengue virus 1 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay Antiviral activity against Dengue virus 1 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay	[PMID: 32435384]
Huh-7	EC₅₀	2.8 μM Compound: 1; PBTZ	Antiviral activity against Dengue virus 3 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay Antiviral activity against Dengue virus 3 infected in human HuH7 cells assessed as reduction in virus replication incubated for 48 hrs by plaque reduction assay	[PMID: 32435384]
Vero C1008	CC₅₀	>100 μM Compound: HeE1-2Tyr	Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 37159959]
Vero C1008	IC₅₀	6.8 μM Compound: 40	Antiviral activity against DENV1 Djibouti infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis Antiviral activity against DENV1 Djibouti infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis	[PMID: 31128447]
Vero C1008	IC₅₀	6.8 μM Compound: 40	Antiviral activity against DENV2 Martinique infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis Antiviral activity against DENV2 Martinique infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis	[PMID: 31128447]
Vero C1008	IC₅₀	6.8 μM Compound: 40	Antiviral activity against DENV3 Bolivia infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis Antiviral activity against DENV3 Bolivia infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis	[PMID: 31128447]
Vero C1008	IC₅₀	6.8 μM Compound: 40	Antiviral activity against DENV4 Dakar infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis Antiviral activity against DENV4 Dakar infected in African green monkey Vero E6 cells after 3 to 4 days by RT-PCR analysis	[PMID: 31128447]

In Vitro

HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC₅₀ of 2.1 μM, as well as all the four Dengue virus (DENV) serotypes, with IC₅₀ ranging from 6.8 to 15 μM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 μM^[1].
Additionally, upon infection of human HEK 293 cells (CC₅₀ of 50 μM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC₅₀ values ranging from 3.9 to 12 μM^[1].
HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2245195-67-7
Appearance Solid
Molecular Weight 582.67
Formel C₃₃H₃₀N₂O₆S
Color White to yellow
SMILES

OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC(C(C=C2C3=CC=CC=C3)=C4SC5=CC=C(OC6CCCCC6)C=C5N4C2=O)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

PLoS Pathog

TRIM14 restricts tembusu virus infection through degrading viral NS1 protein and activating type I interferon signaling. [Abstract]

2025 May 28;21(5):e1013200. PMID: 40435148

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (171.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7162 mL

8.5812 mL

17.1624 mL

5 mM

0.3432 mL

1.7162 mL

3.4325 mL

10 mM

0.1716 mL

0.8581 mL

1.7162 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Delia Tarantino, et al. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res. 2016 Oct;134:226-235. [Content Brief]

[2]. Milan Dejmek, et al. Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication. Viruses. 2021 Aug 11;13(8):1585. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7162 mL	8.5812 mL	17.1624 mL	42.9059 mL
	5 mM	0.3432 mL	1.7162 mL	3.4325 mL	8.5812 mL
	10 mM	0.1716 mL	0.8581 mL	1.7162 mL	4.2906 mL
	15 mM	0.1144 mL	0.5721 mL	1.1442 mL	2.8604 mL
	20 mM	0.0858 mL	0.4291 mL	0.8581 mL	2.1453 mL
	25 mM	0.0686 mL	0.3432 mL	0.6865 mL	1.7162 mL
	30 mM	0.0572 mL	0.2860 mL	0.5721 mL	1.4302 mL
	40 mM	0.0429 mL	0.2145 mL	0.4291 mL	1.0726 mL
	50 mM	0.0343 mL	0.1716 mL	0.3432 mL	0.8581 mL
	60 mM	0.0286 mL	0.1430 mL	0.2860 mL	0.7151 mL
	80 mM	0.0215 mL	0.1073 mL	0.2145 mL	0.5363 mL
	100 mM	0.0172 mL	0.0858 mL	0.1716 mL	0.4291 mL

Keywords

HeE1-2Tyr

1 Cited Publications

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HeE1-2Tyr

Anti-Infection Compound Library

Cell Cycle/DNA Damage Compound Library

Antiviral Compound Library

Anti-Aging Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) HeE1-2Tyr

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

HeE1-2Tyr

Anti-Infection Compound Library

Cell Cycle/DNA Damage Compound Library

Antiviral Compound Library

Anti-Aging Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) HeE1-2Tyr

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

HeE1-2Tyr Related Classifications

HY-100749 Related Classifications