HO 221
HO 221 is an orally active benzoylphenylurea derivative with antitumor activity. HO 221 can inhibit the activity of mammalian DNA polymerase alpha. HO 221 can induce G1 phase arrest. HO 221 can be used for the research of cancer, such as leukemia.
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- CAS. Nr.: 105128-93-6
- Formel: C18H11BrClN5O5
- Molecular Weight:492.67
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
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DNA Polymerase |
Chemical Information
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CAS. Nr. 105128-93-6
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Molecular Weight 492.67
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Formel C18H11BrClN5O5
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SMILES
ClC1=C(OC2=NC=C(Br)C=N2)C=CC(NC(NC(C3=C(C=CC=C3)[N+]([O-])=O)=O)=O)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Nakajima T, et al. Antitumor activity on murine tumors of a novel antitumor benzoylphenylurea derivative, HO-221. Cancer Chemother Pharmacol. 1991;28(5):351-6. [Content Brief]
[2]. Nakajima T, et al. Mechanism of tumor cell killing by HO-221, a novel antitumor compound. Cancer Chemother Pharmacol. 1990;27(3):199-204. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HO 221 Related Classifications
HY-106787 Related Classifications
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