Art. -Nr.: HY-124808

IMM-01

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IMM-01 is a mammalian Diaphanous (mDia)-related formins agonist that inhibits DID-DAD (diaphanous inhibitory domain-diaphanous autoregulatory domain) binding with an IC₅₀ of 140 nM. IMM-01 acts by disrupting the autoinhibitory bond between the DID and DAD domain and thus activates formins. IMM-01 shows anticancer effects.

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Reinheit: 99.12%
CAS. Nr.: 218795-74-5
Formel: C₁₂H₁₇N₃O₂S
Molecular Weight:267.35

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

IMM-01 Chemical Structure

CAS. Nr.: 218795-74-5

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Ras Isoform-spezifische Produkte anzeigen :

In Vitro

IMM-01 (100 μM; 1h) induces microtubule stabilization in SW480 colon carcinoma cells^[1].
IMM-01 (10 μM) significantly induces LacZ expression in NIH 3T3-SRE-LacZ cells^[1].
IMM-01 (1-100 μM; 48 hours) induces caspase-3 cleavage during induction of apoptosis in NIH 3T3 cells and SW480 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

NIH 3T3 cells and SW480 cells
Concentration:

1 μM, 10 μM, or 100 μM
Incubation Time:

48 hours
Result:

Induced caspase-3 cleavage.

In Vivo

IMM-01 (5-25 mg/kg; i.v.; 2 times a week; for 3 weeks) is able to slow tumor growth in a mouse xenograft model of colon cancer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Athymic nude female mice (6 to 8 weeks) implanted with SW480 cells^[1]
Dosage:

5 mg/kg, 25 mg/kg
Administration:

i.v.; 2 times a week; for 3 weeks
Result:

Slowed tumor growth in a dose-dependent manner when administered intravenously via the tail vein.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 218795-74-5
Appearance Solid
Molecular Weight 267.35
Formel C₁₂H₁₇N₃O₂S
Color Light yellow to light brown
SMILES

OC1=CC=C(/C=N/NC(NC(C)(C)C)=S)C(O)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (467.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.7404 mL

18.7021 mL

37.4041 mL

5 mM

0.7481 mL

3.7404 mL

7.4808 mL

10 mM

0.3740 mL

1.8702 mL

3.7404 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. L Leanne Lash, et al. Small-molecule intramimics of formin autoinhibition: a new strategy to target the cytoskeletal remodeling machinery in cancer cells. Cancer Res. 2013 Nov 15;73(22):6793-803. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.7404 mL	18.7021 mL	37.4042 mL	93.5104 mL
	5 mM	0.7481 mL	3.7404 mL	7.4808 mL	18.7021 mL
	10 mM	0.3740 mL	1.8702 mL	3.7404 mL	9.3510 mL
	15 mM	0.2494 mL	1.2468 mL	2.4936 mL	6.2340 mL
	20 mM	0.1870 mL	0.9351 mL	1.8702 mL	4.6755 mL
	25 mM	0.1496 mL	0.7481 mL	1.4962 mL	3.7404 mL
	30 mM	0.1247 mL	0.6234 mL	1.2468 mL	3.1170 mL
	40 mM	0.0935 mL	0.4676 mL	0.9351 mL	2.3378 mL
	50 mM	0.0748 mL	0.3740 mL	0.7481 mL	1.8702 mL
	60 mM	0.0623 mL	0.3117 mL	0.6234 mL	1.5585 mL
	80 mM	0.0468 mL	0.2338 mL	0.4676 mL	1.1689 mL
	100 mM	0.0374 mL	0.1870 mL	0.3740 mL	0.9351 mL

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IMM-01

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Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Alle Ras Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

IMM-01

Apoptosis Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

MAPK Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Cell Death Library

Bioactive Compound Library Max

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Alle Ras Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

IMM-01 Related Classifications

HY-124808 Related Classifications