country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-162365

Copy Link Print Information

JD-02

JD-02 is a novel Hsp90 inhibitor. JD-02 can induce autophagy and apoptosis. JD-02 increses the level of reactive oxygen species.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₃H₃₂N₆O₂
Molecular Weight:424.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

JD-02 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

JD-02 is a novel Hsp90 inhibitor. JD-02 can induce autophagy and apoptosis. JD-02 increses the level of reactive oxygen species^[1].

Alle HSP Isoform-spezifische Produkte anzeigen :

In Vitro

JD-02 (0-2 μM, 24, 48, and 72 h) inhibits growth and in HTC116 and SW620 cells^[1].
JD-02 (1 μM, 36 h) induces G0/G1 phase arrest in HTC116 and SW620 cells^[1].
JD-02 (1 μM, 48 h) induces cell apoptosis in HTC116 and SW620 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HTC116 and SW620 cells
Concentration:

0–2 μM
Incubation Time:

24, 48, and 72 h
Result:

Inhibited cell growth.

Apoptosis Analysis^[1]

Cell Line:

HTC116 and SW620 cells
Concentration:

1 μM
Incubation Time:

48 h.
Result:

Induced cell apoptosis.

Cell Cycle Analysis^[1]

Cell Line:

HTC116 and SW620 cells
Concentration:

1 μM
Incubation Time:

36 h
Result:

Induced G0/G1 phase arrest.

In Vivo

JD-02 (5, 10, and 20 mg/kg for i.p; 21 days) decreases tumor development in HCT116 cell xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HCT116 cell xenograft mouse model^[1]
Dosage:

5, 10, and 20 mg/kg
Administration:

Intravenous injection for 21 days
Result:

decreased tumor development by 64.3%.

Chemical Information

Molecular Weight 424.54
Formel C₂₃H₃₂N₆O₂
SMILES

CC1=NN(C2=CC=C(C(N)=O)C(N[C@@H]3CC[C@@H](O)CC3)=C2)C4=C1/C(CC(C)(C)C4)=N/N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lan N, et al. JD-02, a novel Hsp90 inhibitor, induces ROS/SRC axis-dependent cytoprotective autophagy in colorectal cancer cells. Mol Carcinog. Published online February 27, 2024. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

JD-02

Alle HSP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

JD-02 Related Classifications

HY-162365 Related Classifications