KARS-IN-1
KARS-IN-1 (152) is a AKR1C3 dependent KARS inhibitor with an AC50 of 9.1 nM for human KARS. KARS-IN-1 shows anti-proliferative activity in H460 (NRF2 pathway mutant cell line with high AKR1C3 expression) and Hara (NRF2 pathway wild type cell line with low AKR1C3 expression), with AC50 values ??of 21 nM and 16 nM, respectively. KARS-IN-1 can be used for the study of non-small cell lung cancer (NSCLC).
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- CAS. Nr.: 2579083-99-9
- Formel: C21H23F2N3O2
- Molecular Weight:387.42
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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CAS. Nr. 2579083-99-9
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Molecular Weight 387.42
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Formel C21H23F2N3O2
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SMILES
FC(C=C1)=CC=C1CNC(N(CC2)CCC32C[C@@H](O)C4=CC(F)=CC=C4N3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KARS-IN-1 Related Classifications
HY-180562 Related Classifications
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