L-I-OddU
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis.
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- CAS. Nr.: 207920-87-4
- Formel: C8H9IN2O5
- Molecular Weight:340.07
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
L-I-OddU (1 μM; H1 cells) inhibits Epstein-Barr virus (EBV) replication and decreases the linear form of EBV DNA[1].
L-I-OddU (0.25-2 μM; 24 h; H1 and L5 cells) has a major metabolite is L-I-OddUMP and increases the amount of the mono- and diphosphate metabolites formed in H1 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 207920-87-4
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Molecular Weight 340.07
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Formel C8H9IN2O5
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SMILES
OC[C@@H]1O[C@H](N(C=C(C(N2)=O)I)C2=O)CO1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Kira T, et, al. Anti-Epstein-Barr virus (EBV) activity of beta-L-5-iododioxolane uracil is dependent on EBV thymidine kinase. Antimicrob Agents Chemother. 2000 Dec;44(12):3278-84. [Content Brief]
[2]. Focher F, et, al. Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development. Curr Drug Targets Infect Disord. 2003 Mar;3(1):41-53. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
L-I-OddU Related Classifications
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