Lalistat 1
Based on 2 publication(s) in Google Scholar
Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC50 of 68 nM. Lalistat 1 is a inhibitor of immunoglobulin A1 protease (IgA1P) proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.). Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.75%
- CAS. Nr.: 501104-16-1
- Formel: C12H18N4O3S
- Molecular Weight:298.37
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Publications Citing Use of MedChemExpress (MCE) Lalistat 1
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Biologische Aktivität
IC50: 68 nM ( human LAL)[1]
Lalistat 1 (0-100 μM) shows activity against different non-typeable H. influenzae (NTHi) IgAP variants from clinical isolates in Elisa assay. It shows a dose-dependent inhibition of IgA1P B1 and B2, but at higher inhibitor concentrations, consistent with the higher expression levels of these variants. Nearly complete inhibition of IgA1P B1 and B2 is observed at 50 μM, with complete inhibition at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 501104-16-1
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Appearance Solid
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Molecular Weight 298.37
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Formel C12H18N4O3S
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Color White to off-white
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SMILES
O=C(N1CCOCC1)OC2=NSN=C2N3CCCCC3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
DMSO : 20 mg/mL (67.03 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Anton I Rosenbaum , et al. Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J Med Chem . 2010 Jul 22;53(14):5281-9. [Content Brief]
[2]. Livia Shehaj, et al. Small-Molecule Inhibitors of Haemophilus influenzae IgA1 Protease.ACS Infect Dis. 2019 Jul 12;5(7):1129-1138. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3516 mL | 16.7578 mL | 33.5157 mL | 83.7891 mL |
| 5 mM | 0.6703 mL | 3.3516 mL | 6.7031 mL | 16.7578 mL | |
| 10 mM | 0.3352 mL | 1.6758 mL | 3.3516 mL | 8.3789 mL | |
| 15 mM | 0.2234 mL | 1.1172 mL | 2.2344 mL | 5.5859 mL | |
| 20 mM | 0.1676 mL | 0.8379 mL | 1.6758 mL | 4.1895 mL | |
| 25 mM | 0.1341 mL | 0.6703 mL | 1.3406 mL | 3.3516 mL | |
| 30 mM | 0.1117 mL | 0.5586 mL | 1.1172 mL | 2.7930 mL | |
| 40 mM | 0.0838 mL | 0.4189 mL | 0.8379 mL | 2.0947 mL | |
| 50 mM | 0.0670 mL | 0.3352 mL | 0.6703 mL | 1.6758 mL | |
| 60 mM | 0.0559 mL | 0.2793 mL | 0.5586 mL | 1.3965 mL |
Lalistat 1 Related Classifications
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