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Lintuzumab

(Synonyms: SGN-33; HuM-195; GLK-33 Antibody)
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Lintuzumab (HUM-195) is an anti-CD33 humanized monoclonal antibody. Lintuzumab reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells. Lintuzumab promotes tumor cell killing through antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) activities against MDR and MDR+ AML cell lines and primary AML patient samples. Lintuzumab enhances survival and reduces tumor burden in mice.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit: 98.09%
  • CAS. Nr.: 166089-32-3
  • Molecular Weight:145.24 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Lintuzumab
  • Experimental Validation Results for Lintuzumab
  • Experimental Validation Results for Lintuzumab
  • Lintuzumab Chemical Structure
    Lintuzumab Chemical Structure
CAS. Nr.: 166089-32-3
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Lintuzumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Siglec-3/CD33 Protein, Human can bind Lintuzumab. The EC50 for this effect is 1.206 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5X106 THP-1 cells with Lintuzumab (HY-P9983, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa, Isotype Control (HY-P99003, blue) was used as the isotype control.

  • Lintuzumab Chemical Structure
    1/16
  • Lintuzumab
  • Immobilized Siglec-3/CD33 Protein, Human can bind Lintuzumab. The EC50 for this effect is 1.206 ng/mL.
  • Flow cytometric analysis of 1.5X106 THP-1 cells with Lintuzumab (HY-P9983, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa, Isotype Control (HY-P99003, blue) was used as the isotype control.